VEGFB - vascular endothelial growth factor B Gene

Also Known as VRF; VEGFL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7423

About VEGFB

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,234,584-64,239,264 (from NCBI)

This gene has 4 transcripts (splice variants), 167 orthologues and 4 paralogues. Broad expression in fat (RPKM 106.2), heart (RPKM 26.1) and 23 other tissues.

Summary

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]

VEGFB Products (2)

mRNA	Protein	Name
NM_001243733.2	NP_001230662.1	vascular endothelial growth factor B isoform VEGFB-167 precursor
NM_003377.5	NP_003368.1	vascular endothelial growth factor B isoform VEGFB-186 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chemoattractant activity	IDA IDA: Inferred from direct assay	19275959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11122379	GOA
enables vascular endothelial growth factor receptor 1 binding	IPI IPI: Inferred from physical interaction	12366396	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in induction of positive chemotaxis	IDA IDA: Inferred from direct assay	19275959	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	18259607	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	18259607	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	18259607	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18259607	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	8637916	GOA
involved in positive regulation of mast cell chemotaxis	IDA IDA: Inferred from direct assay	19275959	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11122379	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	18259607	GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	18259607	GOA
NOT involved in positive regulation of vascular permeability	IDA IDA: Inferred from direct assay	16109918	GOA
involved in positive regulation of vascular wound healing	IDA IDA: Inferred from direct assay	16109918	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	8637916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VEGFB Protein Structure

PDGF

0
100
207 a.a.

Protein Preferred Names	Protein Names
vascular endothelial growth factor B	VEGF-related factor

VEGFB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VEGFB	P49765	KLHL12	Homo sapiens	Q53G59	Validated Y2H	32296183
Intra	VEGFB	P49765	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	VEGFB	P49765	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VEGFB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72431	VEGF-B Protein, Human (HEK293, Fc)	P49765 (P22-A207)	≥ 95%, as determined by reducing SDS-PAGE.

VEGFB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82882	VEGFB Antibody (YA2627)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Blood Group, Globoside System	Globe Disease GLOB Blood Group System, Globoside
Kuhnt-Junius Degeneration	Neovascular Age-Related Macular Degeneration Exudative Senile Macular Degeneration Of Retina Senile Macular Degeneration, Wet Wet Senile Macular Retinal Degeneration Exudative Age-Related Macular Degeneration Exudative Macular Degeneration
Macular Retinal Edema	Macular Edema Macular Oedema Macular Retinal Oedema Macular Edema, Cystoid
Retinal Vascular Occlusion	Retinal Vasc. Occlusion Occlusion Of Retinal Vessels Retinal Obstruction
Diabetic Macular Edema
Neovascular Glaucoma	Glaucoma, Neovascular Secondary Angle-Closure Glaucoma With Rubeosis Glaucoma Neovascular
Endophthalmitis
Central Retinal Vein Occlusion	Crvo
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Degeneration Of Macula And Posterior Pole	Degeneration Of Macula And Posterior Pole Of Retina Degeneration Of Macula Or Posterior Pole Macular Degeneration Nos Degenerative Disorder Of Macula Drusen Macular Degeneration Posterior Pole Macular Degeneration Of Eye Macular Eye Degeneration Macular Degeneration Of Retina, Unspecified Pseudohole Degeneration Of Macula Of Retina
Retinal Perforation	Retinal Break Retinal Perforations Retinal Dialysis Retinal Tear Retinal Break Nos Ruptured Retina
Cleidocranial Dysplasia	Cleidocranial Dysostosis CLCD Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly CCD Marie-Sainton Disease Dysplasia Cleidocranial Dento-Osseous Dysplasia Marie-Sainton Syndrome Dysplasia, Cleidocranial
Retinal Artery Occlusion	Retina Artery Narrowing Retinal Artery Spasm Spasm Of Ophthalmic Artery Retinal Spasm Vasospasm Of Retina
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Malignant Renovascular Hypertension	Secondary Malignant Renovascular Hypertension
Ureteric Orifice Cancer	Malignant Neoplasm Of Ureteric Orifice Of Urinary Bladder Malignant Tumor Of Ureteric Orifice Orifice Of The Ureter
Degenerative Myopia	Pathological Myopia Myopia, Degenerative Degenerative Progressive High Myopia Progressive High Myopia Progressive High Myopia
Familiar Ovarian Carcinoma
Severe Nonproliferative Diabetic Retinopathy	High Risk Non Proliferative Diabetic Retinopathy Severe Npdr
Background Diabetic Retinopathy	Non Proliferative Diabetic Retinopathy Non-Proliferative Diabetic Retinopathy Nonproliferative Diabetic Retinopathy
Gastroesophageal Junction Adenocarcinoma	Adenocarcinoma Of Cardioesophageal Junction Adenocarcinoma Of Gastroesophageal Junction Adenocarcinoma Of The Gastroesophageal Junction
Retinal Vascular Disease	Retinal Vascular Retinal Vascular Disorder Retina Circulation Disorder
Vein Disease	Disorder Of Vein
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Exudative Vitreoretinopathy 1	Retinopathy Of Prematurity Retrolental Fibroplasia EVR1 Criswick-Schepens Syndrome Rop Exudative Vitreoretinopathy, Familial, Autosomal Dominant Fevr, Autosomal Dominant Premature Retinopathy Vitreoretinopathy, Exudative 1 Autosomal Dominant Familial Exudative Vitreoretinopathy Fevr Vitreoretinopathy, Exudative, Type 1 Retinopathy Of Prematurity Nos Rlf- [Retrolental Fibroplasia] Rop - [Retinopathy Of Prematurity] Terry Syndrome
Malignant Secondary Hypertension
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99830	Conbercept	Inhibitor	98.42%	Phase 4
HY-P990540	Anti-VEGFB Antibody (CSL346)		≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10831	GNQWFI	Antagonist	99.45%	Unkown
HY-P10550	VGB4	Antagonist	/	Unkown
HY-RS15636	VEGFB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174509	Human VEGFB mRNA		/	Unkown
HY-RS18083	Vegfb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24557	Vegfb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	VEGFB	VGNC	VGNC:78765
Rattus norvegicus	VEGFB	RGD	RGD:619799
Felis catus	VEGFB	VGNC	VGNC:81095
Bos taurus	VEGFB	VGNC	VGNC:97324
Mus musculus	VEGFB	MGD	MGI:106199
Canis familiaris	VEGFB	VGNC	VGNC:48251
Others	VEGFB	NCBI