Novel antifungal antibiotics octacosamicins A and B. I. Taxonomy, fermentation and isolation, physico-chemical properties and biological activities

  • J Antibiot (Tokyo). 1988 Nov;41(11):1525-32. doi: 10.7164/antibiotics.41.1525.
K Dobashi  1 ,  N Matsuda ,  M Hamada ,  H Naganawa ,  T Takita ,  T Takeuchi
Affiliations
  • 1. Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 3198488 DOI: 10.7164/antibiotics.41.1525
Abstract

Two antifungal Antibiotics octacosamicins A and B were isolated from the culture broth of a strain of actinomycetes, which was identified as a strain of Amycolatopsis. These Antibiotics were isolated by resin adsorption and purified by column chromatography and preparative HPLC. Both Antibiotics were found to be new substances from their physico-chemical properties. They showed broad Antifungal spectra.

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