2361575-20-2
Chemical Structure
MAGLi 432
- CAS No.: 2361575-20-2
- Formula:C22H24BrClN2O2
- Molecular Weight:463.80
IUPAC Name: (2-bromo-3-methoxyphenyl)((7R,9aR)-7-(4-chlorophenyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl)methanone
InChIKey: BKTASVDLNMGMFP-FUHWJXTLSA-N
SMILES: O=C(C1=CC=CC(OC)=C1Br)N2C[C@](CC[C@H](C3=CC=C(Cl)C=C3)C4)([H])N4CC2
Biological Activity: MAGLi 432 is a non-covalent, potent, highly selective, and reversible MAGL inhibitor. MAGLi 432 binds with high affinity to the MAGL active site, with IC50 values of 4.2 nM (human enzyme) and 3.1 nM (mouse enzyme). MAGLi 432 can be used in the research of chronic inflammation, blood–brain barrier dysfunction, neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease[1].
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MAGLi 432 | MAGLi 432 is a non-covalent, potent, highly selective, and reversible MAGL inhibitor. MAGLi 432 binds with high affinity to the MAGL active site, with IC50 values of 4.2 nM (human enzyme) and 3.1 nM (mouse enzyme). MAGLi 432 can be used in the research of chronic inflammation, blood–brain barrier dysfunction, neurological disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. | |||||||||||||||||||||
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Keywords
