Nptn - neuroplastin Gene

Also Known as SDR-1; Sdfr1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20320

Summary

Predicted to enable cell-cell adhesion mediator activity; transmembrane transporter binding activity; and type 1 Fibroblast Growth Factor receptor binding activity. Involved in cellular calcium ion homeostasis and negative regulation of cytokine production. Acts upstream of or within excitatory synapse assembly; modulation of chemical synaptic transmission; and regulation of receptor localization to synapse. Located in dendrite and immunological synapse. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; nervous system; and respiratory system. Orthologous to human NPTN (neuroplastin). [provided by Alliance of Genome Resources, Apr 2022]

Nptn Products (4)

mRNA Protein Name
NM_001293673.2 NP_001280602.1 neuroplastin isoform 2 precursor
NM_001357751.2 NP_001344680.1 neuroplastin isoform 3 precursor
NM_001406062.1 NP_001392991.1 neuroplastin isoform 4 precursor
NM_009145.3 NP_033171.2 neuroplastin isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28827723 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within excitatory synapse assembly IMP
IMP: Inferred from mutant phenotype
24554721 MGI
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
28827723 MGI
acts upstream of or within modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
24554721 MGI
involved in negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
28827723 MGI
acts upstream of or within regulation of receptor localization to synapse IMP
IMP: Inferred from mutant phenotype
24554721 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
24554721 MGI
Cellular Component GO Annotation Evidence References Source
located in immunological synapse IDA
IDA: Inferred from direct assay
28827723 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroplastin

  • stromal cell derived factor receptor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09504 NPTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19925 Nptn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26427 Nptn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nptn NCBI NCBI:27020