NPTN - neuroplastin Gene

Also Known as GP55; GP65; SDR1; np55; np65; SDFR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27020

About NPTN

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,560,014-73,633,389 (from NCBI)

This gene has 10 transcripts (splice variants), 311 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 67.5), endometrium (RPKM 61.9) and 25 other tissues.

Summary

This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]

NPTN Products (4)

mRNA Protein Name
NM_001161363.2 NP_001154835.1 neuroplastin isoform c precursor
NM_001161364.2 NP_001154836.1 neuroplastin isoform d precursor
NM_012428.4 NP_036560.1 neuroplastin isoform b precursor
NM_017455.4 NP_059429.1 neuroplastin isoform a precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30190470 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPTN Protein Structure

I-set

I-set: Immunoglobulin I-set domain (39 - 121)

Ig_2

Ig_2: Immunoglobulin domain (164 - 228)

I-set

I-set: Immunoglobulin I-set domain (239 - 333)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

neuroplastin

  • SDR-1

Recombinant NPTN Proteins

Cat. No. Product Name Accession Purity
HY-P71153 Neuroplastin Protein, Human (HEK293, His) Q9Y639-1 (Q29-H220) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Erythroleukemia
Retrograde Amnesia

  • Amnesia, Retrograde
Allergic Bronchopulmonary Aspergillosis

  • Aspergillosis, Allergic Bronchopulmonary

  • Abpa

  • Allergic Bronchopulmonary Mycosis

  • Hinson-Pepys Disease

  • Pulmonary Aspergillus Disease

  • Allergic Aspergillosis

  • Aspergillosis Allergic Bronchopulmonary
Acute Erythroid Leukemia

  • Acute Erythroleukemia

  • Di Guglielmo'S Syndrome

  • Aml M6

  • Acute Myeloid Leukemia Fab-M6

  • Acute Myeloid Leukemia M6

  • Erythroleukemia

  • Aml-M6

  • Acute Erythroleukemia M6a Subtype

  • Acute Erythroleukemia M6b Subtype

  • Di Guglielmo Syndrome

  • Acute Myeloid Leukemia, M6 Type

  • Acute Erythroblastic Leukemia

  • Acute Erythroleukemia - M6a Subtype

  • Acute Erythroleukemia - M6b Subtype

  • Acute Erythraemia And Erythroleukaemia

  • Acute Erythroid Leukaemia Without Mention Of Remission

  • Erythraemia

  • Erythraemic Myelosis

  • Erythroleukaemia

  • Acute Erythraemic Myelosis

  • Acute Erythraemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09504 NPTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19925 Nptn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26427 Nptn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NPTN RGD RGD:620296
Macaca mulatta NPTN VGNC VGNC:75202
Canis familiaris NPTN VGNC VGNC:43932
Mus musculus NPTN MGD MGI:108077
Felis catus NPTN VGNC VGNC:63876
Bos taurus NPTN VGNC VGNC:32217
Others NPTN NCBI