SULT1C4 - sulfotransferase family 1C member 4 Gene

Also Known as SULT1C; SULT1C2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27233

About SULT1C4

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:108,377,954-108,388,989 (from NCBI)

This gene has 3 transcripts (splice variants), 256 orthologues and 12 paralogues. Broad expression in gall bladder (RPKM 13.7), ovary (RPKM 9.3) and 15 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008]

SULT1C4 Products (2)

mRNA Protein Name
NM_001321770.2 NP_001308699.1 sulfotransferase 1C4 isoform 2
NM_006588.4 NP_006579.2 sulfotransferase 1C4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aryl sulfotransferase activity IDA
IDA: Inferred from direct assay
17425406 GOA
enables sulfotransferase activity IDA
IDA: Inferred from direct assay
20056724 GOA
Biological Process GO Annotation Evidence References Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in doxorubicin metabolic process IDA
IDA: Inferred from direct assay
26948952 GOA
involved in ethanol catabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in flavonoid metabolic process IDA
IDA: Inferred from direct assay
28222028 GOA
involved in sulfation IDA
IDA: Inferred from direct assay
20056724 GOA
involved in xenobiotic metabolic process IDA
IDA: Inferred from direct assay
26948952 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
28222028 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT1C4 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (45 - 294)

  • 0
  • 100
  • 200
  • 302 a.a.
Protein Preferred Names Protein Names

sulfotransferase 1C4

  • ST1C4

Recombinant SULT1C4 Proteins

Cat. No. Product Name Accession Purity
HY-P71342 SULT1C4 Protein, Human (His) Q6PD90 (M1-K102) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked

  • Christ-Siemens-Touraine Syndrome

  • XHED

  • Ectodermal Dysplasia 1

  • Xlhed

  • Ed1

  • Cst Syndrome

  • Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked

  • Ectd1

  • Ectodermal Dysplasia, Anhidrotic, X-Linked

  • Eda

  • Eda1

  • Hed1

  • Ectodermal Dysplasia 1, Anhidrotic

  • X-Linked Anhidrotic Ectodermal Dysplasia

  • X-Linked Hypohidrotic Ectodermal Dysplasia

  • Hypohidrotic X-Linked Ectodermal Dysplasia

  • Ectodermal Dysplasia, Hypohidrotic, 1

  • Hypohidrotic Ectodermal Dysplasia, X-Linked

  • Anhidrotic Ectodermal Dysplasia X-Linked

  • Hypohidrotic Ectodermal Dysplasia X-Linked

  • Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked

  • Ectodermal Dysplasia Anhidrotic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14018 SULT1C4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SULT1C4 VGNC VGNC:106230
Mus musculus SULT1C4 MGD MGI:102928
Felis catus SULT1C4 VGNC VGNC:65836
Canis familiaris SULT1C4 VGNC VGNC:46978
Others SULT1C4 NCBI