DHDH - dihydrodiol dehydrogenase Gene

Also Known as 2DD; HUM2DD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27294

About DHDH

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,932,795-48,944,969 (from NCBI)

This gene has 4 transcripts (splice variants), 287 orthologues and 3 paralogues. Biased expression in kidney (RPKM 7.4), small intestine (RPKM 4.3) and 5 other tissues.

Summary

This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These Enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]

DHDH Products (1)

mRNA Protein Name
NM_014475.4 NP_055290.1 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

DHDH Protein Structure

GFO_IDH_MocA

GFO_IDH_MocA: Oxidoreductase family, NAD-binding Rossmann fold (3 - 117)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

  • 3-deoxyglucosone reductase

Related Diseases

Diseases Alias
Congenital Myasthenic Syndrome 7

  • Cms7

  • Congenital Myasthenic Syndrome 7 Presynaptic

  • Myasthenic Syndrome, Congenital, Type 7, Presynaptic
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03729 DHDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DHDH VGNC VGNC:39929
Rattus norvegicus DHDH RGD RGD:1588686
Mus musculus DHDH MGD MGI:1919005
Bos taurus DHDH VGNC VGNC:28036
Macaca mulatta DHDH VGNC VGNC:71653
Others DHDH NCBI