GNA12 - G protein subunit alpha 12 Gene

Also Known as RMP; gep; NNX3; HG1M1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2768

About GNA12

Cytogenetic location: 7p22.3-p22.2 Genomic coordinates (GRCh38): 7:2,728,105-2,844,308 (from NCBI)

This gene has 8 transcripts (splice variants), 236 orthologues and 15 paralogues. Ubiquitous expression in placenta (RPKM 20.5), ovary (RPKM 16.5) and 25 other tissues.

Summary

Predicted to enable D5 Dopamine Receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in regulation of TOR signaling and regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

GNA12 Products (4)

mRNA Protein Name
NM_001282440.1 NP_001269369.1 guanine nucleotide-binding protein subunit alpha-12 isoform 2
NM_001282441.2 NP_001269370.1 guanine nucleotide-binding protein subunit alpha-12 isoform 3
NM_001293092.2 NP_001280021.1 guanine nucleotide-binding protein subunit alpha-12 isoform 4
NM_007353.3 NP_031379.2 guanine nucleotide-binding protein subunit alpha-12 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein activity IDA
IDA: Inferred from direct assay
8647866 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10026210 GOA
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
15525651 GOA
enables protein phosphatase regulator activity IDA
IDA: Inferred from direct assay
15525651 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
22609986 GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
22609986 GOA
Cellular Component GO Annotation Evidence References Source
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
15525651 GOA
located in neuron projection IDA
IDA: Inferred from direct assay
15525651 GOA
located in neuronal cell body IDA
IDA: Inferred from direct assay
15525651 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNA12 Protein Structure

G-alpha

G-alpha: G-protein alpha subunit (25 - 370)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein subunit alpha-12

  • WUGSC:H_GS165O14.2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05530 GNA12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GNA12 RGD RGD:71018
Bos taurus GNA12 VGNC VGNC:29445
Macaca mulatta GNA12 VGNC VGNC:73086
Felis catus GNA12 VGNC VGNC:107756
Canis familiaris GNA12 VGNC VGNC:41297
Mus musculus GNA12 MGD MGI:95767
Others GNA12 NCBI