HLA-DPB1 - major histocompatibility complex, class II, DP beta 1 Gene

Also Known as DPB1; HLA-DP; HLA-DPB; HLA-DP1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3115

About HLA-DPB1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,075,990-33,089,696 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 69 orthologues, 13 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 88.0), lymph node (RPKM 85.6) and 22 other tissues.

Summary

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

HLA-DPB1 Products (1)

mRNA	Protein	Name
NM_002121.6	NP_002112.3	HLA class II histocompatibility antigen, DP beta 1 chain precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables peptide antigen binding	IDA IDA: Inferred from direct assay	20356827	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	32341563	GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA IDA: Inferred from direct assay	32341563	GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP IMP: Inferred from mutant phenotype	20356827	GOA
involved in positive regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	20356827	GOA
involved in positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	20356827	GOA
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	20356827	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MHC class II protein complex	IDA IDA: Inferred from direct assay	20356827	GOA
located in cell surface	IMP IMP: Inferred from mutant phenotype	20356827	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DPB1 Protein Structure

MHC_II_beta

C1-set

0
100
200
235 a.a.

Protein Preferred Names	Protein Names
HLA class II histocompatibility antigen, DP beta 1 chain	HLA class II histocompatibility antigen, DP(W4) beta chain

HLA-DPB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HLA-DPB1	P04440	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	HLA-DPB1	P04440	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	HLA-DPB1	P04440	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	HLA-DPB1	P04440	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	HLA-DPB1	P04440	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	HLA-DPB1	P04440	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HLA-DPB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71696	HLA-DPB1 Protein, Human (His)	P04440 (R30-R223)	≥ 90%, as determined by reducing SDS-PAGE.

HLA-DPB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83528	HLA-DPB1 Antibody (YA3273)	WB, IHC-P, ICC/IF, IP	Human
HY-P83528A	HLA-DPB1 Antibody (YA3273)(PBS only)	WB, IHC-P, ICC/IF, IP	Human
HY-P83945	HLA-DPB1 Antibody (YA3642)	IHC-P, FC, ELISA	Human, Rat
HY-P83945A	HLA-DPB1 Antibody (YA3642)(PBS only)	IHC-P, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Chronic Beryllium Disease	Chronic Berylliosis Berylliosis Chronic Beryllium Lung Disease Beryllium Disease Chronic Beryllium Disease, Chronic, Susceptibility To
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Myelitis	Spinal Cord Inflammation Nos Radiculomyelitis Nos Myeloradiculitis
Rubella	German Measles Three Day Measles Rubella Nos
Neuromyelitis Optica	Devic Disease Devic Syndrome Neuromyelitis Optica Spectrum Disorder Devic'S Disease Devic'S Syndrome Devic'S Neuromyelitis Optica Nmo Nmo Spectrum Disorder Neuromyelitis Optica Spectrum Disorders Devic Neuromyelitis Optica Optic-Spinal Ms Opticospinal Ms Nmosd Opticospinal Multiple Sclerosis Devic Ophthalmoneuromyelitis Optic Neuromyelitis Optic Neuroencephalomyelopathy Nmo - [Neuromyelitis Optica] Optic Neuritis With Demyelination
Juvenile Dermatitis Herpetiformis
Takayasu Arteritis	Aortic Arch Syndrome Pulseless Disease Takayasu'S Arteritis Idiopathic Aortitis Young Female Arteritis Aortic Arch Arteritis Aortic Arches Defect Aortic Arch Defects Takayasu Disease Aortic Arch Syndromes Takayasu'S Disease Ta Obliterative Aortitis Aortic Arch Giant-Cell Arteritis Subclavian-Carotid Obstruction Syndrome Idiopathic Medial Aortopathy And Arteriopathy Takayasu Syndrome Obliterative Brachiocephalic Arteritis Syndrome Raeder-Harbitz Syndrome Chronic Subclavian-Carotid Obstruction Syndrome Giant-Cell Aortitis Takayasu Aortitis Nonspecific Aortoarteritis Sclerosing Aortitis And Arteritis Martorell 2 Syndrome Young Female Aortic Arch Arteritis Syndrome
Japanese Encephalitis	Japanese B Encephalitis Je Encephalitis Japanese Encephalitis, Japanese Russian Autumnal Encephalitis Je - [Japanese Encephalitis] Japanese Encephalitis Virus Disease Jbe - [Japanese B Encephalitis} B Type Encephalitis
Myasthenia Gravis	MG Acquired Myasthenia Autoimmune Myasthenia Gravis Erb-Goldflam Disease Mg - [Myasthenia Gravis] Myasthenia Gravis Nos Myasthenia
Mumps	Parotitis Due To Mumps Virus Mumps Nos Epidemic Parotitis Infectious Parotitis
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Juvenile Ankylosing Spondylitis
Berylliosis	Beryllium Poisoning Beryllium Disease Lung Fibrosis With Berylliosis
Mixed Connective Tissue Disease	Sharp Syndrome Mctd Connective Tissue Disease Overlap Syndrome Mixed Collagen Vascular Disease Mctd - [Mixed Connective Tissue Disease]
Inflammatory Bowel Disease 18	IBD18
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Apple Allergy	Malus Domestica Fruit Allergy
Byssinosis	Flax-Dressers' Disease Cotton Mill Fever Stripper'S Asthma Monday Morning Fever Cotton Workers' Lung Disease Cotton-Dust Asthma Mill Fever Lung Fibrosis With Byssinosis Airway Disease Due To Cotton Dust Respiratory Tract Disorder Due To Cotton Dust Strippers' Disease Flax-Dressers' Disorder Strippers' Asthma
Tuberculous Epididymitis	Tuberculosis Of Epididymis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Occupational Asthma
Environmental Induced Asthma	Irritant Asthma
Subacute Lymphocytic Thyroiditis
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Iridocyclitis	Primary Iridocyclitis
West Nile Encephalitis	West-Nile Encephalitis West Nile Fever West Nile Fever Encephalitis West Nile Fever With Encephalitis West-Nile Fever Encephalitis, West Nile Fever
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Diabetes Mellitus	Diabetes
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06203	HLA-DPA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06204	HLA-DPB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06212	HLA-DRB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown