PARP6 - poly(ADP-ribose) polymerase family member 6 Gene

Also Known as ARTD17; pART17; PARP-6-C; PARP-6-B1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56965

About PARP6

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:72,241,181-72,272,554 (from NCBI)

This gene has 23 transcripts (splice variants), 180 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 26.3), thyroid (RPKM 13.7) and 25 other tissues.

Summary

Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. [provided by Alliance of Genome Resources, Apr 2022]

PARP6 Products (14)

mRNA Protein Name
NM_001323515.2 NP_001310444.1 protein mono-ADP-ribosyltransferase PARP6 isoform 2
NM_001323516.2 NP_001310445.1 protein mono-ADP-ribosyltransferase PARP6 isoform 2
NM_001323519.2 NP_001310448.1 protein mono-ADP-ribosyltransferase PARP6 isoform 3
NM_001323521.2 NP_001310450.1 protein mono-ADP-ribosyltransferase PARP6 isoform 3
NM_001323522.2 NP_001310451.1 protein mono-ADP-ribosyltransferase PARP6 isoform 1
NM_001323523.2 NP_001310452.1 protein mono-ADP-ribosyltransferase PARP6 isoform 3
NM_001323524.2 NP_001310453.1 protein mono-ADP-ribosyltransferase PARP6 isoform 3
NM_001323525.2 NP_001310454.1 protein mono-ADP-ribosyltransferase PARP6 isoform 4
NM_001323526.2 NP_001310455.1 protein mono-ADP-ribosyltransferase PARP6 isoform 3
NM_001323528.2 NP_001310457.1 protein mono-ADP-ribosyltransferase PARP6 isoform 4
NM_001323530.2 NP_001310459.1 protein mono-ADP-ribosyltransferase PARP6 isoform 2
NM_001323531.2 NP_001310460.1 protein mono-ADP-ribosyltransferase PARP6 isoform 4
NM_001323532.2 NP_001310461.1 protein mono-ADP-ribosyltransferase PARP6 isoform 1
NM_020214.4 NP_064599.2 protein mono-ADP-ribosyltransferase PARP6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NAD+-protein-aspartate ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
25043379 GOA
enables NAD+-protein-cysteine ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
25043379 GOA
Biological Process GO Annotation Evidence References Source
involved in protein auto-ADP-ribosylation IDA
IDA: Inferred from direct assay
25043379 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP6 Protein Structure

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (456 - 526)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 630 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP6

  • ADP-ribosyltransferase diphtheria toxin-like 17

Related Diseases

Diseases Alias
Diphtheria

  • Corynebacterium Infections

  • Corynebacterium Infection

  • Diphtherial Infection

  • Infection Due To Corynebacterium Diphtheriae
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-119653 AZ9482 Inhibitor 99.80% Unkown
HY-145749 PARPYnD Inhibitor 98.86% Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-125217 PARP10-IN-1 Inhibitor / Unkown
HY-RS10069 PARP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21013 Parp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27530 Parp6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PARP6 MGD MGI:1914537
Bos taurus PARP6 VGNC VGNC:53578
Canis familiaris PARP6 VGNC VGNC:59122
Felis catus PARP6 VGNC VGNC:104353
Rattus norvegicus PARP6 RGD RGD:1310937
Others PARP6 NCBI