RPP21 - ribonuclease P/MRP subunit p21 Gene

Also Known as CAT60; C6orf135

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79897

About RPP21

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,345,156-30,346,857 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 162 orthologues. Ubiquitous expression in endometrium (RPKM 10.7), ovary (RPKM 10.6) and 25 other tissues.

Summary

RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]

RPP21 Products (3)

mRNA	Protein	Name
NM_001199120.3	NP_001186049.1	ribonuclease P protein subunit p21 isoform 1
NM_001199121.3	NP_001186050.1	ribonuclease P protein subunit p21 isoform 3
NM_024839.4	NP_079115.1	ribonuclease P protein subunit p21 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15096576	GOA
enables ribonuclease P RNA binding	IDA IDA: Inferred from direct assay	16723659	GOA
contributes to ribonuclease P activity	IDA IDA: Inferred from direct assay	30454648	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18291362	GOA
involved in tRNA 5'-leader removal	IDA IDA: Inferred from direct assay	16723659	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of multimeric ribonuclease P complex	IDA IDA: Inferred from direct assay	16723659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPP21 Protein Structure

Rpr2

0
100
154 a.a.

Protein Preferred Names	Protein Names
ribonuclease P protein subunit p21	RNaseP protein p21

RPP21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPP21	Q9H633	RPP40	Homo sapiens	O75818	Anti Tag CoIP	33961781
Intra	RPP21	Q9H633	RPP40	Homo sapiens	O75818	Anti Tag CoIP	30454648

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Anauxetic Dysplasia 2	ANXD2
Anauxetic Dysplasia 1	Anauxetic Dysplasia Spondylometaepiphyseal Dysplasia, Menger Type Spondylometaepiphyseal Dysplasia, Anauxetic Type Spondyloepimetaphyseal Dysplasia, Anauxetic Type ANXD1 Anxd Spondylometaepiphyseal Dysplasia Anauxetic Type Spondylometaepiphyseal Dysplasia Menger Type Ad Spondyloepimetaphyseal Dysplasia, Menger Type Dysplasia, Anauxetic, Type 1
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12213	RPP21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPP21	VGNC	VGNC:102509
Bos taurus	RPP21	VGNC	VGNC:106902
Canis familiaris	RPP21	VGNC	VGNC:54354
Rattus norvegicus	RPP21	RGD	RGD:1303090
Mus musculus	RPP21	MGD	MGI:1914926
Others	RPP21	NCBI