2077083-94-2
Chemical Structure
Antifungal agent 31
- CAS 番号: 2077083-94-2
- Formula:C25H22F2N6O3
- Molecular Weight:492.48
IUPAC Name: 3-((2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)-7-(4-methoxyphenyl)pyrrolo[1,2-d][1,2,4]triazin-4(3H)-one
InChIKey: SQVRHWIZZFOWBI-PUAOIOHZSA-N
SMILES: O=C1N([C@H](C)[C@@](O)(C2=CC=C(F)C=C2F)CN3N=CN=C3)N=CC4=CC(C5=CC=C(OC)C=C5)=CN14
Biological Activity: Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections[1].
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Antifungal agent 31 | Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections. | |||||||||||||||||||||
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Keywords
