2299177-09-4
Chemical Structure
Nelutroctiv
Synonym(s): CK-136
- CAS 番号: 2299177-09-4
- Formula:C24H22F5N3O4S
- Molecular Weight:543.51
IUPAC Name: (1R,3R,5R)-N-((R)-cyclopropyl(2,5-difluoro-4-(trifluoromethyl)phenyl)methyl)-2-(5-(methylsulfonyl)nicotinoyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide
InChIKey: BDIJXTIDFAIBQF-OOCUOIDPSA-N
SMILES: O=C(C1=CN=CC(S(C)(=O)=O)=C1)N2[C@@]3([H])[C@](C[C@@H]2C(N[C@H](C4CC4)C5=C(C=C(C(F)=C5)C(F)(F)F)F)=O)([H])C3
Biological Activity: Nelutroctiv (CK-136) is an orally active and selective cardiac troponin activator. Nelutroctiv activates cardiac sarcomeres by enhancing the sensitivity of troponin to calcium ions and promoting the interaction between actin and myosin. Nelutroctiv enhances cardiac contractility. Nelutroctiv can be used in the researches for cardiovascular diseases with impaired cardiac contractile function[1][2].
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Nelutroctiv | 99.57% | Nelutroctiv (CK-136) is an orally active and selective cardiac troponin activator. Nelutroctiv activates cardiac sarcomeres by enhancing the sensitivity of troponin to calcium ions and promoting the interaction between actin and myosin. Nelutroctiv enhances cardiac contractility. Nelutroctiv can be used in the researches for cardiovascular diseases with impaired cardiac contractile function. | ||||||||||||||||||||
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- [1]. Jani V P, et al. The small-molecule troponin activator CK-136 increases myocyte contractility in human heart failure. Biophysical Journal, 2024, 123(3): 402a.
- [2]. Romero A, et al. Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility. J Med Chem. 2024 May 23;67(10):7825-7835. [Content Brief]
Keywords
