country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-N17465

Copy Link Print Information

Dendronobiloside D

Dendronobiloside D is a sesquiterpene glycoside that can be isolated from Dendrobium officinale. Dendronobiloside D is an immunosuppressant that promotes the differentiation of CD4⁺ T cells into Treg cells.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 526222-27-5
分子式: C₂₇H₄₄O₁₂
分子量:560.63

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Dendronobiloside D 構造式

CAS 番号: 526222-27-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

IL-12

Interleukin Related アイソフォーム固有の製品をすべて表示 :

体外実験

Dendronobiloside D downregulated the expression of IFNG, IL-6, and IL-12 mRNA in primary T cells, and upregulated the expression of TGFB mRNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_0-t	AUC_0-∞	C_max	T_max	T_1/2	CL_z/F	V_z/F
Rat^[1]	6.25 g/kg	p.o.	14.38 ± 1.72 μg/L·h	17.29 ± 1.99 μM/L·h	2.28 ± 0.18 μg/L	1.50 ± 0.55 h	5.72 ± 2.91 h	6.11 ± 0.74 L/h/kg	26.36 ± 32.39 L/kg

体内実験

Dendronobiloside D (6.25 g/kg; p.o.; single dose), administered as part of a Dendrobium nobile aqueous extract to rats, shows low plasma exposure with a C_max of 2.28 ± 0.18 μg/L, rapid absorption with a T_max of 1.50 h, and a terminal elimination half-life of 5.72 h^[2].
Dendronobiloside D (6.25 g/kg; i.g.; single dose), administered as part of a Dendrobium nobile aqueous extract to rats, distributes widely to visceral and gastrointestinal tissues (excluding the brain) with highest concentrations in the small intestine, stomach, and large intestine^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats (male, 6-8 weeks old, 220±20 g)^[1]
Dosage:

6.25 g/kg (equivalent raw herb dose, as component of Dendrobium nobile aqueous extract)
Administration:

i.g.; single dose
Result:

Was detectable in all collected tissues except the brain.
Reached distribution concentration peaks generally within 2 hours post-administration.
Showed declining distribution concentrations between 2 and 6 hours post-administration.
Had tissue distribution levels ranked as: small intestine > stomach > large intestine > pancreas > lungs > kidneys > liver > heart > thymus > spleen > brain (undetectable).
Exhibited concentrations in the gastrointestinal tract (small intestine, stomach, large intestine) approximately 30 times higher than in heart, thymus, and spleen.

化学情報

CAS 番号 526222-27-5
分子量 560.63
分子式 C₂₇H₄₄O₁₂
SMILES

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OCC2=C3[C@](C=C(CC3)C)([H])[C@@H](CC2)C(C)CO[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wu X, et al. Pharmacokinetics and tissue distribution of key sesquiterpene glycosides in Dendrobium nobile analyzed by UHPLC-Q-Trap-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2025;1250:124386. [Content Brief]

[2]. Wu X, et al. Capture and Validation of T Cell Modulatory Bioactive Constituents from Dendrobium nobile Using Biolayer Interferometry Coupled with UHPLC-Q-TOF MS/MS[J].

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

お問い合わせ在庫あり

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Dendronobiloside D

High-Throughput Bioactive Compound Library

Interleukin Related アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Dendronobiloside D 関連分類

HY-N17465 関連分類