CTDSPL - CTD small phosphatase like Gene

Also Known as PSR1; SCP3; HYA22; RBSP3; C3orf8

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10217

About CTDSPL

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:37,861,880-37,984,469 (from NCBI)

This gene has 8 transcripts (splice variants), 254 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 20.1), gall bladder (RPKM 14.9) and 25 other tissues.

Summary

Predicted to enable RNA polymerase II CTD heptapeptide repeat Phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

CTDSPL Products (2)

mRNA Protein Name
NM_001008392.2 NP_001008393.1 CTD small phosphatase-like protein isoform 1
NM_005808.3 NP_005799.2 CTD small phosphatase-like protein isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
16882717 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTDSPL Protein Structure

NIF

NIF: NLI interacting factor-like phosphatase (107 - 266)

  • 0
  • 100
  • 200
  • 276 a.a.
Protein Preferred Names Protein Names

CTD small phosphatase-like protein

  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

関連疾患

Diseases Alias
Granulomatous Disease, Chronic, Autosomal Recessive, 2

  • Chronic Granulomatous Disease Due To Deficiency Of Ncf-2

  • CGD2

  • Ncf2 Deficiency

  • P67-Phox Deficiency

  • Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii

  • Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2

  • Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii

  • Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii

  • Granulomatous Disease, Chronic, Due To Ncf2 Deficiency

  • Neutrophil Cytosol Factor 2 Deficiency

  • Chronic Granulomatous Disease 2, Autosomal Recessive

  • Autosomal Recessive Chronic Granulomatous Disease 2

  • Cdg2

  • Deficiency Of Ncf2

  • Deficiency Of P67-Phox

  • Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii

  • Deficiency Of Neutrophil Cytosol Factor 2

  • Avellino Corneal Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03293 CTDSPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03294 CTDSPL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta CTDSPL VGNC VGNC:71425
Rattus norvegicus CTDSPL RGD RGD:1304841
Bos taurus CTDSPL VGNC VGNC:106702
Felis catus CTDSPL VGNC VGNC:61249
Mus musculus CTDSPL MGD MGI:1916524
Others CTDSPL NCBI