CENPA - centromere protein A Gene

Also Known as CenH3; CENP-A

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 1058

About CENPA

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,786,056-26,794,589 (from NCBI)

This gene has 6 transcripts (splice variants), 213 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 4.5), appendix (RPKM 2.5) and 14 other tissues.

Summary

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

CENPA Products (2)

mRNA	Protein	Name
NM_001042426.2	NP_001035891.1	histone H3-like centromeric protein A isoform b
NM_001809.4	NP_001800.1	histone H3-like centromeric protein A isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	19410544	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in CENP-A containing chromatin assembly	IDA IDA: Inferred from direct assay	11682612	GOA
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	19468067	GOA
involved in kinetochore assembly	IDA IDA: Inferred from direct assay	11682612	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	27499292	GOA
involved in protein localization to chromosome, centromeric region	IDA IDA: Inferred from direct assay	11682612	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of CENP-A containing nucleosome	IDA IDA: Inferred from direct assay	18195732	GOA
part of CENP-A containing nucleosome	IPI IPI: Inferred from physical interaction	21743476	GOA
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	11084331	GOA
located in condensed chromosome, centromeric region	IDA IDA: Inferred from direct assay	11682612	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	27499292	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27499292	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPA Protein Structure

Histone

0
100
140 a.a.

Protein Preferred Names	Protein Names
histone H3-like centromeric protein A	centromere autoantigen A

CENPA Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CENPA	P49450	H4C16	Homo sapiens	P62805	X-Ray Diffraction	21478274
Intra	CENPA	P49450	H4C16	Homo sapiens	P62805	GMS	21478274
Intra	CENPA	P49450	H4C16	Homo sapiens	P62805	TAP	19410544
Intra	CENPA	P49450	H4C16	Homo sapiens	P62805	GMS	26167883
Intra	CENPA	P49450	MCM2	Homo sapiens	P49736	GMS	26167883
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	TAP	19410544
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	X-Ray Diffraction	21478274
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	GMS	21478274
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	35271311
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Density Sedimentation	19410544
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Bait CoIP	19410545
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	19410545
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Pull Down	19410545
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	26496610
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	33961781
Intra	CENPA	P49450	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	CENPA	P49450	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	CENPA	P49450	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

CENPA 抗体

製品番号	製品名	アプリケーション	反応性
HY-P81580	CENPA Antibody (YA1325)	WB, ICC/IF	Human
HY-P81908	CENPA Antibody (YA1653)	WB	Human
HY-P81908A	CENPA Antibody (YA1653)(PBS only)	WB	Human
HY-P86162	CENPA Antibody (YA5854)	WB, ICC/IF, IP, ELISA	Human

関連疾患

Diseases	Alias
Luminal Breast Carcinoma A	Breast Tumor Luminal Luminal A Breast Carcinoma Luminal Breast Cancer
Crest Syndrome
Dyskinesia Of Esophagus	Esophageal Motility Disorders Dyskinesia Of Oesophagus Esophageal Dysmotility Esophageal Motility Disorder Oesophageal Dysmotility Oesophageal Motor Disorder Esophageal Spasm
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Esophageal Leukoplakia	Leukoplakia Of Esophagus
Hyperoxaluria, Primary, Type I	Primary Hyperoxaluria Type 1 HP1 Glycolic Aciduria Alanine-Glyoxylate Aminotransferase Deficiency Hepatic Agt Deficiency Oxalosis I Primary Hyperoxaluria, Type I Serine:Pyruvate Aminotransferase Deficiency Hyperoxaluria, Primary, Type 1 Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency Serine Pyruvate Aminotransferase Deficiency Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Oxalosis 1 Hyperoxaluria Primary 1 Hyperoxaluria Primary Type I Ph1 Primary Hyperoxaluria Type I Oxalosis Type 1 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Telangiectasis	Telangiectasia
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Retinitis Pigmentosa 11	RP11 Retinitis Pigmentosa-11 Retinitis Pigmentosa, Type 11
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS02473	CENPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19662	Cenpa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26155	Cenpa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	CENPA	RGD	RGD:1563607
Mus musculus	CENPA	MGD	MGI:88375
Felis catus	CENPA	VGNC	VGNC:60752
Macaca mulatta	CENPA	VGNC	VGNC:71005
Canis familiaris	CENPA	VGNC	VGNC:39101
Others	CENPA	NCBI