IFITM2 - interferon induced transmembrane protein 2 Gene

Also Known as 1-8D; DSPA2c

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10581

About IFITM2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:307,816-309,395 (from NCBI)

This gene has 23 transcripts (splice variants), 246 orthologues and 4 paralogues. Ubiquitous expression in appendix (RPKM 262.7), spleen (RPKM 209.9) and 23 other tissues.

Summary

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced Antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

IFITM2 Products (1)

mRNA Protein Name
NM_006435.3 NP_006426.2 interferon-induced transmembrane protein 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence 参考文献 由来
involved in cellular response to interferon-beta IDA
IDA: Inferred from direct assay
33563656 GOA
involved in negative regulation of viral entry into host cell IDA
IDA: Inferred from direct assay
21253575 GOA
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
21253575 GOA
involved in response to interferon-alpha IDA
IDA: Inferred from direct assay
22479637 GOA
involved in response to interferon-beta IDA
IDA: Inferred from direct assay
21253575 GOA
involved in response to type II interferon IDA
IDA: Inferred from direct assay
21253575 GOA
involved in response to virus IDA
IDA: Inferred from direct assay
20943977 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in late endosome membrane IDA
IDA: Inferred from direct assay
26354436 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
26354436 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
28246125 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFITM2 Protein Structure

CD225

CD225: Interferon-induced transmembrane protein (42 - 121)

  • 0
  • 100
  • 132 a.a.
Protein Preferred Names Protein Names

interferon-induced transmembrane protein 2

  • dispanin subfamily A member 2c

関連疾患

Diseases Alias
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
West Nile Virus

  • West Nile Virus, Susceptibility To

  • Wnv

  • Wnv, Susceptibility To

  • West Nile Viral Infection

  • Encephalitis, West Nile Fever

  • West Nile Fever
Dengue Virus

  • Dengue Virus, Susceptibility To

  • Dengue Fever, Protection Against

  • Dengue Fever
Stomatitis
Rift Valley Fever

  • Rfv - [Rift Valley Fever]
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS06567 IFITM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21869 Ifitm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28386 Ifitm2 Rat Pre-designed siRNA Set A / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P992379 IB001 Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus IFITM2 MGD MGI:1933382
Rattus norvegicus IFITM2 RGD RGD:69332
Others IFITM2 NCBI