HRH3 - histamine receptor H3 Gene
Also Known as HH3R; GPCR97
生物種: Homo sapiens
About HRH3
This gene has 2 transcripts (splice variants), 117 orthologues and 25 paralogues. Biased expression in brain (RPKM 2.9), testis (RPKM 0.2) and 2 other tissues.
Summary
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
HRH3 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| XM_005260266.4 | XP_005260323.1 | histamine H3 receptor isoform X1 |
| XM_017027623.2 | XP_016883112.2 | histamine H3 receptor isoform X2 |
| NM_007232.3 | NP_009163.2 | histamine H3 receptor |
HRH3 Protein Structure
7tm_1: 7 transmembrane receptor (rhodopsin family) (51 - 412)
- 0
- 100
- 200
- 300
- 400
- 445 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
histamine H3 receptor |
|
HRH3 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P82956 | HRH3 Antibody (YA2701) | WB, ICC/IF, FC | Human, Mouse, Rat |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Body Mass Index Quantitative Trait Locus 11 |
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| Recurrent Hypersomnia |
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| Central Nervous System Disease |
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| Alzheimer Disease, Familial, 1 |
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| Migraine With Or Without Aura 1 |
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| Sleep Disorder |
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| Attention Deficit-Hyperactivity Disorder |
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| Parkinson Disease, Late-Onset |
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| Kleine-Levin Hibernation Syndrome |
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| Chronic Tic Disorder |
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| Schizophrenia |
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Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Felis catus | HRH3 | VGNC | VGNC:80113 |
| Macaca mulatta | HRH3 | VGNC | VGNC:73524 |
| Rattus norvegicus | HRH3 | RGD | RGD:620630 |
| Bos taurus | HRH3 | VGNC | VGNC:29955 |
| Mus musculus | HRH3 | MGD | MGI:2139279 |
| Canis familiaris | HRH3 | VGNC | VGNC:54313 |
| Others | HRH3 | NCBI |