Acsl6 - acyl-CoA synthetase long-chain family member 6 Gene

Also Known as Facl6; Lacsl

生物種: Rattus norvegicus

遺伝子タイプ: protein coding

遺伝子ID: 117243

Summary

Enables arachidonate-CoA Ligase activity and protein homodimerization activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of long-chain fatty acid import across plasma membrane; and triglyceride biosynthetic process. Located in nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Apr 2022]

Acsl6 Products (1)

mRNA	Protein	Name
NM_130739.2	NP_570095.2	long-chain-fatty-acid--CoA ligase 6

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables arachidonate-CoA ligase activity	IDA IDA: Inferred from direct assay	28209804	RGD
enables long-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	1569043	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	20429931	RGD

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	16428347	RGD
involved in fatty acid transport	IGI IGI: Inferred from genetic interaction	16466685	RGD
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	1569043	RGD
involved in long-chain fatty-acyl-CoA biosynthetic process	IGI IGI: Inferred from genetic interaction	16466685	RGD
involved in neuron development	IEP IEP: Inferred from expression pattern	16848632	RGD
involved in phospholipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	15655248	RGD
involved in positive regulation of long-chain fatty acid import across plasma membrane	IMP IMP: Inferred from mutant phenotype	15655248	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	15051725	RGD
involved in response to gravity	IEP IEP: Inferred from expression pattern	16848632	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15942958	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	16772660	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	11118002	RGD
involved in triglyceride biosynthetic process	IGI IGI: Inferred from genetic interaction	16466685	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
long-chain-fatty-acid--CoA ligase 6	LACS 6 arachidonate--CoA ligase fatty acid Coenzyme A ligase, long chain 6 long-chain acyl-CoA synthetase 6 long-chain-fatty-acid--CoA ligase, brain isozyme

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	純度	Rare Diseases
HY-RS20850	Acsl6 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS00204	ACSL6 Human Pre-designed siRNA Set A	/	Unkown
HY-RS27364	Acsl6 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Acsl6	NCBI	NCBI:23305