2. Gene
  3. ACSL6 - acyl-CoA synthetase long chain family member 6 Gene

ACSL6 - acyl-CoA synthetase long chain family member 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACS2; FACL6; LACS2; LACS5; LACS 6

Gene ID: 23305 | Gene type: protein coding

About ACSL6

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:131,949,973-132,012,068 (from NCBI)

This gene has 34 transcripts (splice variants), 472 orthologues, 12 paralogues and is associated with 73 phenotypes. Biased expression in brain (RPKM 19.2), testis (RPKM 8.4) and 5 other tissues.

Summary

The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]

ACSL6 Products(22)

mRNA Protein Name
NM_001009185.3 NP_001009185.1 long-chain-fatty-acid--CoA ligase 6 isoform b
NM_001205247.2 NP_001192176.1 long-chain-fatty-acid--CoA ligase 6 isoform c
NM_001205248.2 NP_001192177.1 long-chain-fatty-acid--CoA ligase 6 isoform d
NM_001205250.1 NP_001192179.1 long-chain-fatty-acid--CoA ligase 6 isoform e
NM_001205251.2 NP_001192180.1 long-chain-fatty-acid--CoA ligase 6 isoform f
NM_001405475.1 NP_001392404.1 long-chain-fatty-acid--CoA ligase 6 isoform g
NM_001405476.1 NP_001392405.1 long-chain-fatty-acid--CoA ligase 6 isoform h
NM_001405477.1 NP_001392406.1 long-chain-fatty-acid--CoA ligase 6 isoform i
NM_001405478.1 NP_001392407.1 long-chain-fatty-acid--CoA ligase 6 isoform j
NM_001405479.1 NP_001392408.1 long-chain-fatty-acid--CoA ligase 6 isoform k
NM_001405480.1 NP_001392409.1 long-chain-fatty-acid--CoA ligase 6 isoform k
NM_001405481.1 NP_001392410.1 long-chain-fatty-acid--CoA ligase 6 isoform d
NM_001405482.1 NP_001392411.1 long-chain-fatty-acid--CoA ligase 6 isoform k
NM_001405483.1 NP_001392412.1 long-chain-fatty-acid--CoA ligase 6 isoform k
NM_001405484.1 NP_001392413.1 long-chain-fatty-acid--CoA ligase 6 isoform d
NM_001405485.1 NP_001392414.1 long-chain-fatty-acid--CoA ligase 6 isoform l
NM_001405486.1 NP_001392415.1 long-chain-fatty-acid--CoA ligase 6 isoform m
NM_001405487.1 NP_001392416.1 long-chain-fatty-acid--CoA ligase 6 isoform n
NM_001405488.1 NP_001392417.1 long-chain-fatty-acid--CoA ligase 6 isoform n
NM_001405489.1 NP_001392418.1 long-chain-fatty-acid--CoA ligase 6 isoform o
NM_001405490.1 NP_001392419.1 long-chain-fatty-acid--CoA ligase 6 isoform f
NM_015256.4 NP_056071.2 long-chain-fatty-acid--CoA ligase 6 isoform a

ACSL6 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (116 - 562)

  • 0
  • 200
  • 400
  • 600
  • 697 a.a.
Protein Preferred Names Protein Names

long-chain-fatty-acid--CoA ligase 6

arachidonate--CoA ligase

Related Diseases

Diseases Alias
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Her2-Receptor Negative Breast Cancer
Chronic Eosinophilic Leukemia

Pdgfra-Associated Chronic Eosinophilic Leukemia
Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence

Fads

Fetal Akinesia Sequence

FADS1

Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

Pena-Shokeir Syndrome Type 1

Fetal Akinesia Deformation Sequence Syndrome

Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

Pena-Shokeir Syndrome, Type I

Foetal Akinesia Deformation Sequence Syndrome

Foetal Akinesia Sequence

Fetal Akinesia Deformation Sequence Syndrome 1

Pena-Shokeir Syndrome, Type 1

Pena Shokeir Syndrome, Type 1

Akinesia, Fetal, Deformation Sequence

Akinesia, Fetal, Deformation Sequence, Type 1

Pena-Shokeir Syndrome Type I
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00204 ACSL6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACSL6 MGD MGI:894291
Felis catus ACSL6 VGNC VGNC:102151
Rattus norvegicus ACSL6 RGD RGD:69403
Bos taurus ACSL6 VGNC VGNC:55153
Canis familiaris ACSL6 VGNC VGNC:51694