DGKK - diacylglycerol kinase kappa Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 139189

About DGKK

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:50,365,409-50,470,825 (from NCBI)

This gene has 1 transcript (splice variant), 103 orthologues and 9 paralogues. Biased expression in adrenal (RPKM 2.2), brain (RPKM 0.3) and 1 other tissue.

Summary

The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]

DGKK Products (1)

mRNA Protein Name
NM_001013742.4 NP_001013764.1 diacylglycerol kinase kappa

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: Inferred from direct assay
16210324 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in diacylglycerol metabolic process IDA
IDA: Inferred from direct assay
16210324 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
16210324 GOA
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
16210324 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in plasma membrane IDA
IDA: Inferred from direct assay
16210324 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

diacylglycerol kinase kappa

  • 142 kDa diacylglycerol kinase

関連疾患

Diseases Alias
Hypospadias

  • Hypospadias Familial

  • Familial Hypospadias
Nephrotic Syndrome, Type 7

  • Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7

  • NPHS7

  • Nephrotic Syndrome Type 7

  • Ig-Mediated Membranoproliferative Glomerulonephritis

  • Ig-Mediated Mpgn

  • Immunoglobulin-Mediated Mpgn

  • Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis

  • Hemolytic Uremic Syndrome, Atypical 7

  • Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis

  • Hemolytic Uremic Syndrome With Dgke Deficiency

  • Hus With Dgke Deficiency

  • Hemolytic Uremic Syndrome Atypical 7

  • AHUS7

  • Nephrotic Syndrome 7

  • Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03722 DGKK Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus DGKK VGNC VGNC:56703
Mus musculus DGKK MGD MGI:3580254
Canis familiaris DGKK VGNC VGNC:39922
Felis catus DGKK VGNC VGNC:61462
Macaca mulatta DGKK VGNC VGNC:71823
Rattus norvegicus DGKK RGD RGD:1561510
Others DGKK NCBI