KRT24 - keratin 24 Gene

Also Known as K24; KA24; CK-24

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 192666

About KRT24

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,694,246-40,703,752 (from NCBI)

This gene has 1 transcript (splice variant), 114 orthologues and 68 paralogues. Biased expression in esophagus (RPKM 10.1), colon (RPKM 5.1) and 2 other tissues.

Summary

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the Cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009]

KRT24 Products (1)

mRNA	Protein	Name
NM_019016.3	NP_061889.2	keratin, type I cytoskeletal 24

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT24 Protein Structure

Filament

0
100
200
300
400
500
525 a.a.

Protein Preferred Names	Protein Names
keratin, type I cytoskeletal 24	cytokeratin-24

KRT24 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	KRT24	Q2M2I5	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	KRT80	Homo sapiens	Q6KB66-2	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	KRT79	Homo sapiens	Q5XKE5	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	KRT71	Homo sapiens	Q3SY84	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	AARD	Homo sapiens	Q4LEZ3	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	TCHP	Homo sapiens	Q9BT92	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	SGF29	Homo sapiens	Q96ES7	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	KRT24	Q2M2I5	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Naegeli-Franceschetti-Jadassohn Syndrome	Naegeli Syndrome Nfj Syndrome NFJS Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis Dpr Franceschetti-Jadassohn Syndrome Nfjs/Dpr
Retinitis Pigmentosa 42	RP42 Retinitis Pigmentosa-42 Retinitis Pigmentosa, Type 42
Dermatopathia Pigmentosa Reticularis	DPR
Ectodermal Dysplasia 4, Hair/Nail Type	Pure Hair And Nail Ectodermal Dysplasia ECTD4 Ectodermal Dysplasia, Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair/Nail Type Hned Hair-Nail Ectodermal Dysplasia Phned Ectodermal Dysplasia Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair-Nail Type Dysplasia, Ectodermal, Type 4, Hair/Nail
Brill-Zinsser Disease	Recrudescent Typhus Brill Disease Brill Zinsser Disease Brill'S Disease Latent Typhus Sporadic Typhus Typhus, Epidemic Louse-Borne Recrudescent Typhus Due To Rickettsia Prowazekii Recrudescent Typhus Fever Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii Recrudescent Brill Disease Recrudescent Typhus Fever Due To Rickettsia Prowazekii
Autosomal Dominant Severe Congenital Neutropenia	Severe Congenital Neutropenia Autosomal Dominant Neutropenia, Congenital, Severe, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS07448	KRT24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	KRT24	RGD	RGD:1303157
Canis familiaris	KRT24	VGNC	VGNC:42523
Felis catus	KRT24	VGNC	VGNC:63170
Mus musculus	KRT24	MGD	MGI:1922956
Bos taurus	KRT24	VGNC	VGNC:30723
Macaca mulatta	KRT24	VGNC	VGNC:99164
Others	KRT24	NCBI