VWCE - von Willebrand factor C and EGF domains Gene

Also Known as VWC1; URG11

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 220001

About VWCE

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,258,286-61,295,316 (from NCBI)

This gene has 7 transcripts (splice variants), 114 orthologues and 19 paralogues. Broad expression in ovary (RPKM 4.8), liver (RPKM 2.1) and 15 other tissues.

Summary

Predicted to enable calcium ion binding activity. Involved in cellular response to virus. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

VWCE Products (1)

mRNA Protein Name
NM_152718.2 NP_689931.2 von Willebrand factor C and EGF domain-containing protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
21653829 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in cellular response to virus IEP
IEP: Inferred from expression pattern
16496348 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
16496348 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VWCE Protein Structure

EGF_CA

EGF_CA: Calcium-binding EGF domain (142 - 179)

EGF_CA

EGF_CA: Calcium-binding EGF domain (181 - 218)

EGF_CA

EGF_CA: Calcium-binding EGF domain (220 - 261)

VWC

VWC: von Willebrand factor type C domain (386 - 440)

VWC

VWC: von Willebrand factor type C domain (501 - 559)

VWC

VWC: von Willebrand factor type C domain (629 - 684)

VWC

VWC: von Willebrand factor type C domain (687 - 742)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 955 a.a.
Protein Preferred Names Protein Names

von Willebrand factor C and EGF domain-containing protein

  • HBV X protein up-regulated gene 11 protein

VWCE Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
VWCE Q96DN2 KRTAP15-1 Homo sapiens Q3LI76
Y2H Array
32296183
Intra
VWCE Q96DN2 KRTAP15-1 Homo sapiens Q3LI76
Y2H Prey Pooling
32296183
Intra
VWCE Q96DN2 NUFIP2 Homo sapiens Q7Z417
Anti Tag CoIP
33961781
Intra
VWCE Q96DN2 NUFIP2 Homo sapiens Q7Z417
Anti Tag CoIP
28514442
Intra
VWCE Q96DN2 NUFIP2 Homo sapiens Q7Z417
Y2H Pooling
21653829
Intra
VWCE Q96DN2 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
VWCE Q96DN2 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
VWCE Q96DN2 ZNF20 Homo sapiens P17024
Y2H Array
32296183
Intra
VWCE Q96DN2 ZNF20 Homo sapiens P17024
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Tarsal-Carpal Coalition Syndrome

  • TCC

  • Tarsal Carpal Coalition Syndrome

  • Nog-Related-Symphalangism Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS15733 VWCE Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta VWCE VGNC VGNC:79617
Rattus norvegicus VWCE RGD RGD:1309910
Felis catus VWCE VGNC VGNC:66996
Bos taurus VWCE VGNC VGNC:36859
Mus musculus VWCE MGD MGI:1919018
Canis familiaris VWCE VGNC VGNC:48327
Others VWCE NCBI