Ifng - interferon gamma Gene

Also Known as If2f; IFNG2

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 25712

Summary

Predicted to enable cytokine activity. Involved in several processes, including negative regulation of cell population proliferation; positive regulation of NMDA glutamate receptor activity; and positive regulation of macromolecule metabolic process. Located in several cellular components, including extracellular space; neuron projection; and perikaryon. Used to study several diseases, including Chagas disease; allergic conjunctivitis; allergic rhinitis; renal fibrosis; and ureteral obstruction. Biomarker of several diseases, including abdominal aortic aneurysm; autoimmune thyroiditis; pulpitis; tongue squamous cell carcinoma; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including ataxia telangiectasia; autoimmune disease (multiple); eczema herpeticum; Factor VIII deficiency; and leukemia (multiple). Orthologous to human IFNG (interferon gamma). [provided by Alliance of Genome Resources, Apr 2022]

Ifng Products (1)

mRNA Protein Name
NM_138880.3 NP_620235.1 interferon gamma precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables cytokine activity IDA
IDA: Inferred from direct assay
20624457 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in microglial cell activation IGI
IGI: Inferred from genetic interaction
27094552 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11940252 RGD
involved in negative regulation of epithelial cell differentiation IDA
IDA: Inferred from direct assay
20624457 RGD
involved in negative regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
1906384 RGD
involved in negative regulation of glomerular mesangial cell proliferation IMP
IMP: Inferred from mutant phenotype
1906384 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20624457 RGD
involved in neuroinflammatory response IDA
IDA: Inferred from direct assay
27235345 RGD
involved in positive regulation of MHC class II biosynthetic process IEP
IEP: Inferred from expression pattern
3127329 RGD
involved in positive regulation of NMDA glutamate receptor activity IGI
IGI: Inferred from genetic interaction
27094552 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
12931271 RGD
involved in positive regulation of cell adhesion IDA
IDA: Inferred from direct assay
2509328 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
20624457 RGD
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
27235345 RGD
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
19355840 RGD
involved in positive regulation of receptor signaling pathway via STAT IDA
IDA: Inferred from direct assay
20624457 RGD
involved in positive regulation of synaptic transmission, cholinergic IDA
IDA: Inferred from direct assay
1900518 RGD
involved in regulation of glial cell proliferation IDA
IDA: Inferred from direct assay
10598324 RGD
involved in regulation of hepatocyte proliferation IDA
IDA: Inferred from direct assay
15799032 RGD
involved in regulation of neuronal action potential IDA
IDA: Inferred from direct assay
7715823 RGD
involved in regulation of the force of heart contraction IDA
IDA: Inferred from direct assay
1900518 RGD
involved in response to tacrolimus IEP
IEP: Inferred from expression pattern
23867624 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19439114 RGD
involved in sensory perception of mechanical stimulus IDA
IDA: Inferred from direct assay
7715823 RGD
involved in type II interferon-mediated signaling pathway IDA
IDA: Inferred from direct assay
20624457 RGD
Cellular Component GO Annotation Evidence 参考文献 由来
located in extracellular space IDA
IDA: Inferred from direct assay
2474612 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
9396771 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon gamma

  • IFN-gamma

  • interferon 2f

Recombinant Ifng Proteins

製品番号 製品名 アクセッション番号 純度
HY-P7095 IFN-gamma Protein, Rat P01581 (G24-C156) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7095A IFN-gamma Protein, Rat (CHO) P01581 (Q23-C156) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73254 IFN-gamma Protein, Rat (HEK293, Fc) P01581 (Q23-C156) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

阻害性抗体 (2)
製品番号 製品名 製品効果
純度 Phase
HY-P99292 Fontolizumab Inhibitor 97.18% Phase 2
HY-P991201 REGN-7257 Inhibitor 95.34% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P10497A EBV BZLF1 (190-197) TFA Inhibitor 98.74% Unkown
HY-P5898 Z-Val-Val-Nle-diazomethylketone Inhibitor / Unkown
HY-149916 A2AR-antagonist-1 Antagonist 96.68% Unkown
HY-P10497 EBV BZLF1 (190-197) Inhibitor / Unkown
HY-RS06587 IFNG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117786 Go 7874 Inhibitor / Unkown
HY-174662 Human IFNG mRNA / Unkown
HY-RS16805 Ifng Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23245 Ifng Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P990324 Anti-AA2AR/Adenosine A2aR Antibody (3F6-9G5) Inhibitor ≥99.0% Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Ifng NCBI NCBI:3458