TECPR1 - tectonin beta-propeller repeat containing 1 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 25851

About TECPR1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:98,214,624-98,252,232 (from NCBI)

This gene has 17 transcripts (splice variants) and 265 orthologues. Ubiquitous expression in spleen (RPKM 7.5), brain (RPKM 6.9) and 25 other tissues.

Summary

This gene encodes a tethering factor involved in Autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and Bacterial pathogens for Autophagy [provided by RefSeq, Nov 2012]

TECPR1 Products (1)

mRNA Protein Name
NM_015395.3 NP_056210.1 tectonin beta-propeller repeat-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
22342342 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20562859 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in autophagosome maturation IMP
IMP: Inferred from mutant phenotype
22342342 GOA
involved in autophagy IDA
IDA: Inferred from direct assay
21575909 GOA
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
25484072 GOA
involved in regulation of autophagosome maturation IMP
IMP: Inferred from mutant phenotype
22342342 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in autophagosome membrane IDA
IDA: Inferred from direct assay
21575909 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
22342342 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TECPR1 Protein Structure

Pex24p

Pex24p: Integral peroxisomal membrane peroxin (70 - 165)

Hyd_WA

Hyd_WA: Propeller (210 - 238)

Hyd_WA

Hyd_WA: Propeller (254 - 282)

Hyd_WA

Hyd_WA: Propeller (302 - 332)

Hyd_WA

Hyd_WA: Propeller (344 - 376)

Pex24p

Pex24p: Integral peroxisomal membrane peroxin (816 - 916)

Hyd_WA

Hyd_WA: Propeller (954 - 983)

Hyd_WA

Hyd_WA: Propeller (999 - 1029)

Hyd_WA

Hyd_WA: Propeller (1045 - 1075)

Hyd_WA

Hyd_WA: Propeller (1087 - 1127)

  • 0
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  • 1000
  • 1165 a.a.
Protein Preferred Names Protein Names

tectonin beta-propeller repeat-containing protein 1

TECPR1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
TECPR1 Q7Z6L1 ATG5 Homo sapiens Q9H1Y0
Anti Tag CoIP
20562859
Intra
TECPR1 Q7Z6L1 ATG5 Homo sapiens Q9H1Y0
Validated Y2H
32296183
Intra
TECPR1 Q7Z6L1 ATG3 Homo sapiens Q9NT62
Anti Tag CoIP
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Esophageal Atresia

  • Tracheoesophageal Fistula

  • Congenital Atresia Of Esophagus

  • Congenital Imperforate Esophagus

  • Imperforate Esophagus

  • Oesophageal Atresia

  • Te Fistula

  • Tef

  • Tracheoesophageal Fistula With Or Without Esophageal Atresia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14347 TECPR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta TECPR1 VGNC VGNC:79348
Felis catus TECPR1 VGNC VGNC:66058
Rattus norvegicus TECPR1 RGD RGD:1306873
Mus musculus TECPR1 MGD MGI:1917631
Canis familiaris TECPR1 VGNC VGNC:47232
Bos taurus TECPR1 VGNC VGNC:106971
Others TECPR1 NCBI