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TECPR1 - tectonin beta-propeller repeat containing 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25851

About TECPR1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:98,214,624-98,252,232 (from NCBI)

This gene has 17 transcripts (splice variants) and 265 orthologues. Ubiquitous expression in spleen (RPKM 7.5), brain (RPKM 6.9) and 25 other tissues.

Summary

This gene encodes a tethering factor involved in Autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and Bacterial pathogens for Autophagy [provided by RefSeq, Nov 2012]

TECPR1 Products (1)

mRNA	Protein	Name
NM_015395.3	NP_056210.1	tectonin beta-propeller repeat-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	22342342	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	22342342	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	21575909	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	25484072	GOA
involved in regulation of autophagosome maturation	IMP IMP: Inferred from mutant phenotype	22342342	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in autophagosome membrane	IDA IDA: Inferred from direct assay	21575909	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	22342342	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TECPR1 Protein Structure

Pex24p

Hyd_WA

Pex24p

Hyd_WA

0
200
400
600
800
1000
1165 a.a.

Protein Preferred Names	Protein Names
tectonin beta-propeller repeat-containing protein 1

TECPR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TECPR1	Q7Z6L1	ATG5	Homo sapiens	Q9H1Y0	Anti Tag CoIP	20562859
Intra	TECPR1	Q7Z6L1	ATG5	Homo sapiens	Q9H1Y0	Validated Y2H	32296183
Intra	TECPR1	Q7Z6L1	ATG3	Homo sapiens	Q9NT62	Anti Tag CoIP	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14347	TECPR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TECPR1	VGNC	VGNC:79348
Felis catus	TECPR1	VGNC	VGNC:66058
Rattus norvegicus	TECPR1	RGD	RGD:1306873
Mus musculus	TECPR1	MGD	MGI:1917631
Canis familiaris	TECPR1	VGNC	VGNC:47232
Bos taurus	TECPR1	VGNC	VGNC:106971
Others	TECPR1	NCBI