Tbx21 - T-box transcription factor 21 Gene

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of T-helper 17 cell lineage commitment; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of gene expression. Predicted to act upstream of or within T cell differentiation; cellular response to organic substance; and positive regulation of isotype switching to IgG isotypes. Predicted to be located in neuronal cell body and nucleus. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Apr 2022]