KLK12 - kallikrein related peptidase 12 Gene

Also Known as KLKL5; KLK-L5

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 43849

About KLK12

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,029,094-51,035,002 (from NCBI)

This gene has 8 transcripts (splice variants), 173 orthologues and 12 paralogues. Biased expression in esophagus (RPKM 4.6), salivary gland (RPKM 1.0) and 4 other tissues.

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

KLK12 Products (7)

mRNA Protein Name
NM_001370125.1 NP_001357054.1 kallikrein-12 isoform 2 precursor
NM_001370126.1 NP_001357055.1 kallikrein-12 isoform 4
NM_001370127.1 NP_001357056.1 kallikrein-12 isoform 3
NM_001370128.1 NP_001357057.1 kallikrein-12 isoform 3
NM_019598.3 NP_062544.1 kallikrein-12 isoform 1 precursor
NM_145894.2 NP_665901.1 kallikrein-12 isoform 2 precursor
NM_145895.2 NP_665902.2 kallikrein-12 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables peptidase activity IDA
IDA: Inferred from direct assay
21628462 GOA
enables serine-type peptidase activity IDA
IDA: Inferred from direct assay
15300858 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in proteolysis IDA
IDA: Inferred from direct assay
21628462 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK12 Protein Structure

Trypsin

Trypsin: Trypsin (22 - 241)

  • 0
  • 100
  • 200
  • 248 a.a.
Protein Preferred Names Protein Names

kallikrein-12

  • kallikrein-like protein 5

関連疾患

Diseases Alias
Autosomal Recessive Congenital Ichthyosis

  • Lamellar Ichthyosis

  • Congenital Ichthyosiform Erythroderma

  • Li

  • Congenital Nonbullous Ichthyosiform Erythroderma

  • Arci

  • Congenital Lamellar Ichthyosis

  • Nonbullous Congenital Ichthyosiform Erythroderma

  • Cie

  • Congenital Non-Bullous Ichthyosiform Erythroderma

  • Erythrodermic Ichthyosis

  • Nbcie

  • Ncie

  • Non-Bullous Congenital Ichthyosiform Erythroderma

  • Collodion Baby

  • Ichthyosis, Lamellar

  • Non Bullous Congenital Ichthyosiform Erythroderma

  • Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

  • Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

  • Collodion Baby Syndrome

  • Ichthyoses, Lamellar

  • Nbie

  • Nonbullous Ichthyosiform Erythroderma

  • Classic Lamellar Ichthyosis

  • Ichthyosiform Erythroderma Nonbullous Congenital

  • Ichthyosiform Erythroderma Congenital

  • Ichthyosis, Congenital, Autosomal Recessive

  • Ichthyosiform Erythroderma, Congenital

  • Collodion Fetus

  • Non-Bullous Ichthyosiform Erythroderma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS07376 KLK12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus KLK12 MGD MGI:1916761
Bos taurus KLK12 VGNC VGNC:30674
Felis catus KLK12 VGNC VGNC:67963
Rattus norvegicus KLK12 RGD RGD:1308975
Macaca mulatta KLK12 VGNC VGNC:74190
Others KLK12 NCBI