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CMPK1 - cytidine/uridine monophosphate kinase 1 Gene

Also Known as CK; CMK; UMK; CMPK; UMPK; UMP-CMPK

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 51727

About CMPK1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:47,333,790-47,378,839 (from NCBI)

This gene has 7 transcripts (splice variants), 125 orthologues and 9 paralogues. Ubiquitous expression in colon (RPKM 74.1), duodenum (RPKM 71.2) and 25 other tissues.

Summary

This gene encodes one of the Enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]

CMPK1 Products (3)

mRNA	Protein	Name
NM_001136140.2	NP_001129612.1	UMP-CMP kinase isoform b
NM_001366135.1	NP_001353064.1	UMP-CMP kinase isoform c
NM_016308.3	NP_057392.1	UMP-CMP kinase isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables UMP kinase activity	IDA IDA: Inferred from direct assay	11912132	GOA
enables nucleoside diphosphate kinase activity	IDA IDA: Inferred from direct assay	23416111	GOA
enables nucleoside monophosphate kinase activity	EXP EXP: Inferred from Experiment	40615	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in UDP biosynthetic process	IDA IDA: Inferred from direct assay	11912132	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMPK1 Protein Structure

ADK

0
100
200
228 a.a.

Protein Preferred Names	Protein Names
UMP-CMP kinase	UMP/CMP kinase

CMPK1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CMPK1	P30085	TTC19	Homo sapiens	Q6DKK2	Anti Tag CoIP	33961781
Intra	CMPK1	P30085	TTC19	Homo sapiens	Q6DKK2	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CMPK1 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P77273	UMP-CMP kinase/CMPK1 Protein, Human (sf9, His, solution)	P30085-1 (M1-G196)	≥ 95%, as determined by reducing SDS-PAGE.

Diseases	Alias
Astrakhan Spotted Fever
Nemaline Myopathy 2	NEM2 Nemaline Myopathy 2, Autosomal Recessive Nemaline Myopathy, Type 2 Neb-Related Nemaline Myopathy Myopathy, Nemaline, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS02861	CMPK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20888	Cmpk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27405	Cmpk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	CMPK1	RGD	RGD:1310116
Bos taurus	CMPK1	VGNC	VGNC:27480
Mus musculus	CMPK1	MGD	MGI:1913838
Canis familiaris	CMPK1	VGNC	VGNC:39379
Felis catus	CMPK1	VGNC	VGNC:80170
Others	CMPK1	NCBI