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RGL3 - ral guanine nucleotide dissociation stimulator like 3 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 57139

About RGL3

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,394,060-11,419,314 (from NCBI)

This gene has 17 transcripts (splice variants), 96 orthologues and 24 paralogues. Broad expression in thyroid (RPKM 19.9), kidney (RPKM 13.4) and 17 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in positive regulation of GTPase activity and small GTPase mediated signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RGL3 Products (2)

mRNA	Protein	Name
NM_001035223.4	NP_001030300.3	ral guanine nucleotide dissociation stimulator-like 3 isoform 2
NM_001161616.3	NP_001155088.2	ral guanine nucleotide dissociation stimulator-like 3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGL3 Protein Structure

RasGEF_N

RasGEF

0
200
400
600
710 a.a.

Protein Preferred Names	Protein Names
ral guanine nucleotide dissociation stimulator-like 3	RalGEF-like protein 3, mouse homolog

RGL3 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	RGL3	Q3MIN7	FAM200A	Homo sapiens	Q8TCP9	Validated Y2H	32296183
Intra	RGL3	Q3MIN7	FAM200A	Homo sapiens	Q8TCP9	Y2H Array	32296183
Intra	RGL3	Q3MIN7	FAM200A	Homo sapiens	Q8TCP9	Y2H Prey Pooling	32296183
Intra	RGL3	Q3MIN7	RIT1	Homo sapiens	Q92963	Y2H Prey Pooling	32296183
Intra	RGL3	Q3MIN7	RIT1	Homo sapiens	Q92963	Validated Y2H	32296183
Intra	RGL3	Q3MIN7	RIT1	Homo sapiens	Q92963	Y2H Array	32296183
Intra	RGL3	Q3MIN7	RIT2	Homo sapiens	Q99578	Y2H Prey Pooling	32296183
Intra	RGL3	Q3MIN7	RIT2	Homo sapiens	Q99578	Validated Y2H	32296183
Intra	RGL3	Q3MIN7	RIT2	Homo sapiens	Q99578	Y2H Array	32296183
Intra	RGL3	Q3MIN7	RRAS2	Homo sapiens	P62070	Y2H Prey Pooling	32296183
Intra	RGL3	Q3MIN7	RRAS2	Homo sapiens	P62070	Y2H Array	32296183
Intra	RGL3	Q3MIN7	NRAS	Homo sapiens	P01111	Y2H Array	32296183
Intra	RGL3	Q3MIN7	NRAS	Homo sapiens	P01111	Y2H Prey Pooling	32296183
Intra	RGL3	Q3MIN7	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	RGL3	Q3MIN7	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	RGL3	Q3MIN7	KLHL12	Homo sapiens	Q53G59	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS11892	RGL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18634	Rgl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	RGL3	VGNC	VGNC:33905
Felis catus	RGL3	VGNC	VGNC:64591
Rattus norvegicus	RGL3	RGD	RGD:1309756
Canis familiaris	RGL3	VGNC	VGNC:45514
Macaca mulatta	RGL3	VGNC	VGNC:76869
Mus musculus	RGL3	MGD	MGI:1918996
Others	RGL3	NCBI