RIT2 - Ras like without CAAX 2 Gene

Also Known as RIN; RIBA; ROC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6014

About RIT2

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:42,743,227-43,115,685 (from NCBI)

This gene has 5 transcripts (splice variants), 102 orthologues and 35 paralogues. Biased expression in brain (RPKM 5.4) and adrenal (RPKM 0.9).

Summary

RIN belongs to the Ras (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]

RIT2 Products (2)

mRNA Protein Name
NM_001272077.2 NP_001259006.1 GTP-binding protein Rit2 isoform 2
NM_002930.4 NP_002921.1 GTP-binding protein Rit2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables calmodulin binding IDA
IDA: Inferred from direct assay
8918462 GOA
NOT enables identical protein binding IDA
IDA: Inferred from direct assay
21957239 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21957239 GOA
enables semaphorin receptor binding IPI
IPI: Inferred from physical interaction
16122393 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
21957239 GOA
involved in maintenance of protein location in cell IMP
IMP: Inferred from mutant phenotype
21957239 GOA
involved in positive regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
16157584 GOA
involved in regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
21957239 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in membrane raft IDA
IDA: Inferred from direct assay
21957239 GOA
located in neuron projection IDA
IDA: Inferred from direct assay
21957239 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16122393 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16122393 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIT2 Protein Structure

Ras

Ras: Ras family (22 - 182)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

GTP-binding protein Rit2

  • GTP-binding protein Roc2

RIT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RIT2 Q99578 SLC6A3 Homo sapiens Q01959
FRET
21957239
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis, Juvenile, With Dementia

  • Juvenile Amyotrophic Lateral Sclerosis With Dementia

  • Als-Dementia Complex
Immunodeficiency 18

  • IMD18

  • Cd3-Epsilon Deficiency

  • Immunodeficiency 18, Scid Variant

  • Cd3epsilon Deficiency

  • Immunodeficiency 18, Severe Combined Immunodeficiency Variant

  • Immunodeficiency, Type 18
Ehrlichiosis

  • Human Ehrlichiosis

  • He

  • Hey
Balo Concentric Sclerosis

  • Balo'S Concentric Sclerosis

  • Balo Disease

  • Diffuse Cerebral Sclerosis Of Schilder

  • Tumefactive Multiple Sclerosis

  • Concentric Demyelination

  • Balo'S Disease

  • Baló Concentric Sclerosis

  • Encephalitis Periaxialis Concentrica

  • Marburg Variant
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12004 RIT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RIT2 VGNC VGNC:45601
Macaca mulatta RIT2 VGNC VGNC:104243
Felis catus RIT2 VGNC VGNC:64645
Rattus norvegicus RIT2 RGD RGD:1307654
Mus musculus RIT2 MGD MGI:108054
Others RIT2 NCBI