DDX31 - DEAD-box helicase 31 Gene
Also Known as PPP1R25
生物種: Homo sapiens
About DDX31
This gene has 5 transcripts (splice variants), 186 orthologues and 38 paralogues. Ubiquitous expression in thyroid (RPKM 4.3), ovary (RPKM 2.4) and 25 other tissues.
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]
DDX31 Products (7)
| mRNA | Protein | Name |
|---|---|---|
| NM_001322340.2 | NP_001309269.2 | probable ATP-dependent RNA helicase DDX31 isoform 3 |
| NM_001322341.2 | NP_001309270.1 | probable ATP-dependent RNA helicase DDX31 isoform 4 |
| NM_001322342.1 | NP_001309271.1 | probable ATP-dependent RNA helicase DDX31 isoform 5 |
| NM_001322343.1 | NP_001309272.1 | probable ATP-dependent RNA helicase DDX31 isoform 6 |
| NM_001322344.2 | NP_001309273.2 | probable ATP-dependent RNA helicase DDX31 isoform 7 |
| NM_022779.9 | NP_073616.7 | probable ATP-dependent RNA helicase DDX31 isoform 1 |
| NM_138620.2 | NP_619526.2 | probable ATP-dependent RNA helicase DDX31 isoform 2 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
23019224 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in ribosome biogenesis |
IMP
IMP: Inferred from mutant phenotype
|
23019224 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| located in nucleolus |
IDA
IDA: Inferred from direct assay
|
23019224 | GOA |
DDX31 Protein Structure
DEAD: DEAD/DEAH box helicase (255 - 431)
Helicase_C: Helicase conserved C-terminal domain (553 - 602)
DUF4217: Domain of unknown function (DUF4217) (642 - 681)
- 0
- 200
- 400
- 600
- 778 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
probable ATP-dependent RNA helicase DDX31 |
|
DDX31 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
DDX31 | Q9H8H2 | SRP14 | Homo sapiens | P37108 | 33961781 | |
|
Intra
|
DDX31 | Q9H8H2 | SRP14 | Homo sapiens | P37108 | 30021884 |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Skin Sarcoma |
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Mus musculus | DDX31 | MGD | MGI:2682639 |
| Felis catus | DDX31 | VGNC | VGNC:61405 |
| Rattus norvegicus | DDX31 | RGD | RGD:1304895 |
| Bos taurus | DDX31 | VGNC | VGNC:27963 |
| Macaca mulatta | DDX31 | VGNC | VGNC:71631 |
| Others | DDX31 | NCBI |