METTL22 - methyltransferase 22, Kin17 lysine Gene

Also Known as C16orf68

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 79091

About METTL22

Cytogenetic location: 16p13.2 Genomic coordinates (GRCh38): 16:8,621,698-8,667,274 (from NCBI)

This gene has 18 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in testis (RPKM 2.7), endometrium (RPKM 1.3) and 25 other tissues.

Summary

This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

METTL22 Products (1)

mRNA Protein Name
NM_024109.4 NP_077014.4 methyltransferase-like protein 22

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
23349634 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23349634 GOA
enables protein methyltransferase activity IDA
IDA: Inferred from direct assay
23349634 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in protein methylation IDA
IDA: Inferred from direct assay
23349634 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in nucleus IDA
IDA: Inferred from direct assay
23349634 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23349634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL22 Protein Structure

Methyltransf_16

Methyltransf_16: Lysine methyltransferase (179 - 337)

  • 0
  • 100
  • 200
  • 300
  • 404 a.a.
Protein Preferred Names Protein Names

methyltransferase-like protein 22

  • LP8272

METTL22 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
METTL22 Q9BUU2 KIN Homo sapiens O60870
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Esophageal Atresia/Tracheoesophageal Fistula

  • Esophageal Atresia And/Or Tracheoesophageal Fistula

  • Tracheoesophageal Fistula With Or Without Esohageal Atresia

  • Esophageal Atresia / Tracheoesophageal Fistula

  • Ea/Tef

  • Esophageal Atresia With Tracheoesophageal Fistula

  • Esophageal Atresia With Or Without Tracheoesophageal Fistula
Histidinemia

  • Histidine Ammonia-Lyase Deficiency

  • Hal Deficiency

  • Histidase Deficiency

  • His Deficiency

  • Histidinuria

  • Hyperhistidinemia

  • HISTID

  • Histidinuria Renal Tubular Defect
Histidine Metabolism Disease

  • Disturbances Of Histidine Metabolism

  • Disorder Of Histidine Metabolism

  • Disturbance Of Histidine Metabolism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS08361 METTL22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus METTL22 VGNC VGNC:63462
Canis familiaris METTL22 VGNC VGNC:43175
Rattus norvegicus METTL22 RGD RGD:1311433
Bos taurus METTL22 VGNC VGNC:31408
Mus musculus METTL22 MGD MGI:2384301
Macaca mulatta METTL22 VGNC VGNC:74602
Others METTL22 NCBI