VASH2 - vasohibin 2 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 79805

About VASH2

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,950,541-212,991,585 (from NCBI)

This gene has 12 transcripts (splice variants), 200 orthologues and 1 paralogue. Broad expression in testis (RPKM 1.7), esophagus (RPKM 1.3) and 20 other tissues.

Summary

Enables actin binding activity; metallocarboxypeptidase activity; and microtubule binding activity. Involved in axon development and proteolysis. Acts upstream of or within cell-cell fusion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

VASH2 Products (4)

mRNA Protein Name
NM_001136474.3 NP_001129946.1 tubulinyl-Tyr carboxypeptidase 2 isoform 2
NM_001136475.3 NP_001129947.1 tubulinyl-Tyr carboxypeptidase 2 isoform 3
NM_001301056.2 NP_001287985.1 tubulinyl-Tyr carboxypeptidase 2 isoform 4
NM_024749.5 NP_079025.2 tubulinyl-Tyr carboxypeptidase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables actin binding IDA
IDA: Inferred from direct assay
29146869 GOA
enables metallocarboxypeptidase activity IDA
IDA: Inferred from direct assay
29146869 GOA
enables metallocarboxypeptidase activity IMP
IMP: Inferred from mutant phenotype
31171830 GOA
enables microtubule binding IDA
IDA: Inferred from direct assay
31324789 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29146869 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in axon development IMP
IMP: Inferred from mutant phenotype
31324789 GOA
acts upstream of or within cell-cell fusion IDA
IDA: Inferred from direct assay
25184477 GOA
acts upstream of or within cell-cell fusion IMP
IMP: Inferred from mutant phenotype
25184477 GOA
acts upstream of or within positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
19204325 GOA
acts upstream of or within positive regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
19204325 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
29146869 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
19204325 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VASH2 Protein Structure

Vasohibin

Vasohibin: Vasohibin (46 - 291)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

tubulinyl-Tyr carboxypeptidase 2

  • testicular tissue protein Li 222

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS15607 VASH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22911 Vash2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29425 Vash2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus VASH2 MGD MGI:2444826
Bos taurus VASH2 VGNC VGNC:36768
Rattus norvegicus VASH2 RGD RGD:1564105
Felis catus VASH2 VGNC VGNC:81206
Macaca mulatta VASH2 VGNC VGNC:79532
Canis familiaris VASH2 VGNC VGNC:48234
Others VASH2 NCBI