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ADAM33 - ADAM metallopeptidase domain 33 Gene

Also Known as C20orf153; DJ964F7.1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 80332

About ADAM33

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,667,975-3,682,010 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues and 20 paralogues. Broad expression in endometrium (RPKM 33.9), gall bladder (RPKM 16.7) and 17 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

ADAM33 Products (3)

mRNA	Protein	Name
NM_001282447.3	NP_001269376.1	disintegrin and metalloproteinase domain-containing protein 33 isoform gamma precursor
NM_025220.5	NP_079496.1	disintegrin and metalloproteinase domain-containing protein 33 isoform alpha preproprotein
NM_153202.4	NP_694882.1	disintegrin and metalloproteinase domain-containing protein 33 isoform beta precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM33 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
813 a.a.

Protein Preferred Names	Protein Names
disintegrin and metalloproteinase domain-containing protein 33	ADAM 33

関連疾患

Diseases	Alias
Childhood-Onset Asthma	Childhood Asthma Asthma Childhood
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Allergic Asthma	Atopic Asthma Extrinsic Asthma Extrinsic Asthma With Acute Exacerbation Extrinsic Asthma With Status Asthmaticus Asthma Allergic Atopic Asthma, Susceptibility To Ige-Mediated Allergic Asthma Allergen-Induced Asthma Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Without Stated Status Asthmaticus Predominantly Allergic Asthma Allergic Asthma Nos Catarrh With Asthma Allergic Bronchitis Nos Extrinsic Allergic Asthma Predominantly Allergic Asthma With Stated Status Asthmaticus
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Near-Fatal Asthma
Occupational Asthma
Environmental Induced Asthma	Irritant Asthma
Intrinsic Asthma	Non-Atopic Asthma
Chronic Asthma
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS00284	ADAM33 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20134	Adam33 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26637	Adam33 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	ADAM33	VGNC	VGNC:59583
Rattus norvegicus	ADAM33	RGD	RGD:1305278
Macaca mulatta	ADAM33	VGNC	VGNC:69409
Canis familiaris	ADAM33	VGNC	VGNC:37585
Mus musculus	ADAM33	MGD	MGI:1341813
Bos taurus	ADAM33	VGNC	VGNC:25611
Others	ADAM33	NCBI