SLC10A7 - solute carrier family 10 member 7 Gene

Also Known as P7; SSASKS; C4orf13

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 84068

About SLC10A7

Cytogenetic location: 4q31.22 Genomic coordinates (GRCh38): 4:146,253,981-146,521,940 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and is associated with 2 phenotypes. Ubiquitous expression in placenta (RPKM 1.0), stomach (RPKM 1.0) and 25 other tissues.

Summary

Enables bile acid transmembrane transporter activity. Involved in several processes, including cellular calcium ion homeostasis; glycoprotein transport; and heparin biosynthetic process. Located in Golgi apparatus and endoplasmic reticulum. Is intrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC10A7 Products (6)

mRNA	Protein	Name
NM_001029998.6	NP_001025169.1	sodium/bile acid cotransporter 7 isoform b
NM_001300842.3	NP_001287771.1	sodium/bile acid cotransporter 7 isoform d
NM_001317816.2	NP_001304745.1	sodium/bile acid cotransporter 7 isoform e
NM_001317817.2	NP_001304746.1	sodium/bile acid cotransporter 7 isoform f
NM_001317818.2	NP_001304747.1	sodium/bile acid cotransporter 7 isoform g
NM_032128.5	NP_115504.1	sodium/bile acid cotransporter 7 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables bile acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	22029531	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in Golgi vesicle transport	IDA IDA: Inferred from direct assay	22029531	GOA
involved in bone development	IMP IMP: Inferred from mutant phenotype	30082715	GOA
involved in glycoprotein transport	IDA IDA: Inferred from direct assay	22029531	GOA
involved in heparin biosynthetic process	IMP IMP: Inferred from mutant phenotype	30082715	GOA
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	30082715	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	29878199	GOA
located in Golgi medial cisterna	IDA IDA: Inferred from direct assay	22029531	GOA
located in cis-Golgi network	IDA IDA: Inferred from direct assay	22029531	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17628207	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17628207	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	22029531	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC10A7 Protein Structure

SBF_like

0
100
200
300
358 a.a.

Protein Preferred Names	Protein Names
sodium/bile acid cotransporter 7	Na(+)/bile acid cotransporter 7

SLC10A7 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	SLC10A7	Q0GE19	DPY19L4	Homo sapiens	Q7Z388	Anti Tag CoIP	28514442
Intra	SLC10A7	Q0GE19	DPY19L4	Homo sapiens	Q7Z388	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Short Stature, Amelogenesis Imperfecta, And Skeletal Dysplasia With Scoliosis	SSASKS
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Spondyloepiphyseal Dysplasia With Congenital Joint Dislocations	Spondyloepiphyseal Dysplasia Chst3-Related Skeletal Dysplasia Humerospinal Dysostosis Spondyloepiphyseal Dysplasia, Omani Type Chondrodysplasia With Multiple Dislocations SEDCJD Hsd Cdmd Humero-Spinal Dysostosis Kozlowski Celermajer Tink Syndrome Chondrodysplasia With Congenital Joint Dislocations, Chst3 Type Larsen Syndrome, Recessive Type Humero-Spinal Dysostosis With Congenital Heart Disease Omani Type Sed Chst3 Deficiency Chst3-Related Dysplasia Recessive Larsen Syndrome Autosomal Recessive Larsen Syndrome Sed With Luxations, Chst3 Type Sed, Omani Type Sdcd, Chst3 Type Spondyloepiphyseal Dysplasia With Congenital Joint Dyslocations, Chst3 Type Sed Omani Type Spondyloepiphyseal Dysplasia Omani Type Larsen Syndrome, Autosomal Recessive Mucopolysaccharidosis Iv Spondyloepiphyseal Dysplasia, Congenita
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 1	Nevo Syndrome Eds Vi Ehlers-Danlos Syndrome, Type Vi Eds Via Ehlers-Danlos Syndrome Type 6 EDSKSCL1 Eds6 Ehlers-Danlos Syndrome Kyphoscoliotic Type 1 Kyphoscoliotic Ehlers-Danlos Syndrome Cutis Hyperelastica Ehlers-Danlos Syndrome Type 6a Ehlers-Danlos Syndrome Oculoscoliotic Type Kyphoscoliotic Eds Kyphoscoliotic Eds Due To Lysyl Hydroxylase 1 Deficiency Kyphoscoliotic Ehlers-Danlos Syndrome Due To Lysyl Hydroxylase 1 Deficiency Lysyl Hydroxylase-Deficient Eds Ocular-Scoliotic Eds Keds Keds-Plod1 Ehlers-Danlos Syndrome, Kyphoscoliotic Type 1 Ehlers-Danlos Syndrome, Ocular-Scoliotic Type Ehlers-Danlos Syndrome, Type Via, Formerly Eds6a, Formerly Eds 6 Eds, Kyphoscoliotic Type Eds, Oculoscoliotic Type Ehlers-Danlos Syndrome, Kyphoscoliosis Type Ehlers-Danlos Syndrome, Kyphoscoliotic Type Ehlers-Danlos Syndrome, Oculoscoliotic Type Eds6a Ehlers-Danlos Syndrome 6 Ehlers-Danlos Syndrome Kyphoscoliotic Type
Desbuquois Dysplasia	Desbuquois Syndrome Micromelic Dwarfism With Vertebral And Metaphyseal Abnormalities And Advanced Carpotarsal Ossification Dysplasia, Desbuquois
Congenital Disorder Of Glycosylation, Type Iik	CDG2K Congenital Disorder Of Glycosylation Type Iik Cdg Iik Cdgiik Carbohydrate Deficient Glycoprotein Syndrome Type Iik Cdg Syndrome Type Iik Congenital Disorder Of Glycosylation Type 2k Tmem165-Cdg Cdg-Iik Cdgiidk Congenital Disorder Of Glycosylation 2k Glycosylation, Congenital Disorder Of, Type Iik
Spondyloepimetaphyseal Dysplasia, Sponastrime Type	Sponastrime Dysplasia Spondylar And Nasal Alterations With Striated Metaphyses SEMDSP Short-Limb Dwarfism With Saddle Nose, Spinal Alterations, And Metaphyseal Striation Spondylar And Nasal Alterations-Striated Metaphyses Syndrome Spondyloepimetaphyseal Dysplasia Sponastrime Type Short Limb Dwarfism With Saddle Nose, Spinal Alterations, And Metaphyseal Striation Spondylar And Nasal Changes With Striations Of The Metaphyses Dysplasia Short Limb Dwarfism With Saddle Nose, Spinal Alterations And Metaphyseal Striation Dysplasia, Spondyloepimetaphyseal, Sponastrime Type
Brachyolmia	Brachyrachia
Scoliosis
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12993	SLC10A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	SLC10A7	VGNC	VGNC:77555
Felis catus	SLC10A7	VGNC	VGNC:65185
Mus musculus	SLC10A7	MGD	MGI:1924025
Canis familiaris	SLC10A7	VGNC	VGNC:46215
Rattus norvegicus	SLC10A7	RGD	RGD:1564388
Bos taurus	SLC10A7	VGNC	VGNC:106930
Others	SLC10A7	NCBI