FTMT - ferritin mitochondrial Gene

Also Known as MTF

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 94033

About FTMT

Cytogenetic location: 5q23.1 Genomic coordinates (GRCh38): 5:121,851,882-121,852,833 (from NCBI)

This gene has 1 transcript (splice variant), 219 orthologues and 3 paralogues.

Summary

Predicted to enable ferric iron binding activity and ferrous iron binding activity. Involved in several processes, including cellular iron ion homeostasis; positive regulation of aconitate hydratase activity; and positive regulation of Succinate Dehydrogenase activity. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

FTMT Products (1)

mRNA	Protein	Name
NM_177478.2	NP_803431.1	ferritin, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables ferroxidase activity	IDA IDA: Inferred from direct assay	11323407	GOA
enables iron ion binding	IDA IDA: Inferred from direct assay	15201052	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in intracellular iron ion homeostasis	IDA IDA: Inferred from direct assay	11323407	GOA
involved in positive regulation of aconitate hydratase activity	IGI IGI: Inferred from genetic interaction	18160053	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18160053	GOA
involved in positive regulation of lyase activity	IDA IDA: Inferred from direct assay	18160053	GOA
involved in positive regulation of succinate dehydrogenase activity	IGI IGI: Inferred from genetic interaction	18160053	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in mitochondrion	IDA IDA: Inferred from direct assay	11323407	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FTMT Protein Structure

Ferritin

0
100
200
242 a.a.

Protein Preferred Names	Protein Names
ferritin, mitochondrial	ferritin H subunit

FTMT 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83608	Mitochondrial Ferritin Antibody (YA3353)	WB	Human

関連疾患

Diseases	Alias
Friedreich Ataxia	Friedreich Ataxia 1 FRDA Friedreich Ataxia With Retained Reflexes Frda1 Fa Friedreich'S Ataxia Hereditary Spinal Ataxia Fa1 Friedreich'S Tabes Hereditary Spinal Sclerosis Spinocerebellar Ataxia, Friedreich Friedreich Spinocerebellar Ataxia Friedrich'S Ataxia
Sideroblastic Anemia	Anemia Sideroblastic Anemia, Sideroblastic Anemia, Hypochromic With Iron Loading
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Spinocerebellar Ataxia 27	Spinocerebellar Ataxia Type 27 SCA27 Cerebellar Ataxia Autosomal Dominant Fgf14-Related Vestibulocerebellar Disorder With Predominant Ocular Signs Cerebellar Ataxia, Autosomal Dominant, Fgf14-Related Nystagmus 4, Congenital, Autosomal Dominant, Formerly Nys4, Formerly Ataxia, Spinocerebellar, Type 27
Bosch-Boonstra-Schaaf Optic Atrophy Syndrome	BBSOAS Optic Atrophy-Intellectual Disability Syndrome
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Hyperferritinemia With Or Without Cataract	Hyperferritinemia-Cataract Syndrome Hhcs Hereditary Hyperferritinemia With Congenital Cataracts Hyperferritinemia, Hereditary, With Congenital Cataracts Bonneau-Beaumont Syndrome HRFTC Hereditary Hyperferritinemia-Cataract Syndrome Cataract-Hyperferritinemia Syndrome Hyperferritinemia Cataract Syndrome Hereditary Hyperferritinemia Cataract Syndrome
Aceruloplasminemia	Cerebellar Ataxia Hypoceruloplasminemia Hemosiderosis, Systemic, Due To Aceruloplasminemia Familial Apoceruloplasmin Deficiency Hereditary Ceruloplasmin Deficiency Deficiency Of Ferroxidase Hypoceruloplasminemia, Hereditary Ceruloplasmin Deficiency Systemic Hemosiderosis Due To Aceruloplasminemia ACERULOP

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS05135	FTMT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20735	Ftmt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27247	Ftmt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	FTMT	RGD	RGD:1306563
Macaca mulatta	FTMT	VGNC	VGNC:110463
Mus musculus	FTMT	MGD	MGI:1914884
Bos taurus	FTMT	VGNC	VGNC:52235
Others	FTMT	NCBI