(-)-Gallopamil
(-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil is promising for research of antiarrhythmics.
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- CAS 番号: 36622-40-9
- 分子式: C28H40N2O5
- 分子量:484.63
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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Calcium Channel アイソフォーム固有の製品をすべて表示
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生物活性
化学情報
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CAS 番号 36622-40-9
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分子量 484.63
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分子式 C28H40N2O5
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SMILES
N#C[C@](CCCN(C)CCC1=CC=C(C(OC)=C1)OC)(C2=CC(OC)=C(C(OC)=C2)OC)C(C)C
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別名
(-)-Methoxyverapamil
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Sokolov S, et al. On the role of Ca(2+)- and voltage-dependent inactivation in Ca(v)1.2 sensitivity for the phenylalkylamine (-)gallopamil. Circ Res. 2001 Oct 12;89(8):700-8. [Content Brief]
[2]. Sokolov S, et al. Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil. J Physiol. 1999 Sep 1;519 Pt 2(Pt 2):315-22. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(-)-Gallopamil 関連分類
HY-118202 関連分類
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