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Cat. No.: HY-118202A

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(-)-Gallopamil hydrochloride

(Synonyms: (-)-Methoxyverapamil hydrochloride)

(-)-Gallopamil (hydrochloride) exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil (hydrochloride) inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil (hydrochloride) also accelerates the voltage-dependent phase of I_Ca decay (as well as the voltage-dependent decay of Ba²⁺ currents). (-)-Gallopamil (hydrochloride) is promising for research of antiarrhythmics.

For research use only. We do not sell to patients.

CAS No.: 36622-39-6
Formula: C₂₈H₄₁ClN₂O₅
Molecular Weight:521.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

(-)-Gallopamil hydrochloride Chemical Structure

CAS No.: 36622-39-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Calcium Channel Isoforms :

Chemical Information

CAS No. 36622-39-6
Molecular Weight 521.09
Formula C₂₈H₄₁ClN₂O₅
SMILES

N#C[C@](C(C)C)(CCCN(CCC1=CC=C(OC)C(OC)=C1)C)C2=CC(OC)=C(OC)C(OC)=C2.Cl
Synonyms

(-)-Methoxyverapamil hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sokolov S, et al. On the role of Ca(2+)- and voltage-dependent inactivation in Ca(v)1.2 sensitivity for the phenylalkylamine (-)gallopamil. Circ Res. 2001 Oct 12;89(8):700-8. [Content Brief]

[2]. Sokolov S, et al. Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil. J Physiol. 1999 Sep 1;519 Pt 2(Pt 2):315-22. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(-)-Gallopamil hydrochloride

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(-)-Gallopamil hydrochloride Related Classifications

HY-118202A Related Classifications