1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Gallopamil hydrochloride

Gallopamil hydrochloride (Synonyms: Methoxyverapamil hydrochloride)

Cat. No.: HY-14276A Purity: >98.0%
Handling Instructions

Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent.

For research use only. We do not sell to patients.

Gallopamil hydrochloride Chemical Structure

Gallopamil hydrochloride Chemical Structure

CAS No. : 16662-46-7

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10 mM * 1 mL in DMSO USD 96 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].

IC50 & Target

Ca2+

 

In Vivo

Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate[3].

Animal Model: Male Wistar rats weighing 290-370 g[3]
Dosage: 0.2 mg/kg
Administration: i.v.; 5 min
Result: Markedly reduced VT and totally prevented VF.
Clinical Trial
Molecular Weight

521.09

Formula

C₂₈H₄₁ClN₂O₅

CAS No.

16662-46-7

SMILES

COC1=C(OC)C(OC)=CC(C(CCCN(C)CCC2=CC(OC)=C(OC)C=C2)(C#N)C(C)C)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

Purity: >98.0%

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Keywords:

GallopamilMethoxyverapamilCalcium ChannelCa2+ channelsCa channelsVerapamilphenylalkylaminecalciumantiarrhythmicvasodilatorInhibitorinhibitorinhibit

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Product name:
Gallopamil hydrochloride
Cat. No.:
HY-14276A
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