1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Gallopamil

Gallopamil (Synonyms: Methoxyverapamil)

Cat. No.: HY-14276 Purity: >98.0%
Handling Instructions

Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent.

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Gallopamil Chemical Structure

Gallopamil Chemical Structure

CAS No. : 16662-47-8

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 96 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 Get quote
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil is a potent antiarrhythmic and vasodilator agent[3].

IC50 & Target

Ca2+

 

In Vivo

Gallopamil (Methoxyverapamil; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate[3].

Animal Model: Male Wistar rats weighing 290-370 g[3]
Dosage: 0.2 mg/kg
Administration: i.v.; 5 min
Result: Markedly reduced VT and totally prevented VF.
Clinical Trial
Molecular Weight

484.63

Formula

C₂₈H₄₀N₂O₅

CAS No.

16662-47-8

SMILES

COC1=C(OC)C(OC)=CC(C(CCCN(C)CCC2=CC(OC)=C(OC)C=C2)(C#N)C(C)C)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0634 mL 10.3171 mL 20.6343 mL
5 mM 0.4127 mL 2.0634 mL 4.1269 mL
10 mM 0.2063 mL 1.0317 mL 2.0634 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.16 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

GallopamilMethoxyverapamilCalcium ChannelCa2+ channelsCa channelsVerapamilphenylalkylaminecalciumantiarrhythmicvasodilatorInhibitorinhibitorinhibit

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Gallopamil
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