16662-47-8
Chemical Structure
Gallopamil
Synonym(s): Methoxyverapamil
- CAS No.: 16662-47-8
- Formula:C28H40N2O5
- Molecular Weight:484.63
IUPAC Name: 5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile
InChIKey: XQLWNAFCTODIRK-UHFFFAOYSA-N
SMILES: COC1=C(OC)C(OC)=CC(C(CCCN(C)CCC2=CC(OC)=C(OC)C=C2)(C#N)C(C)C)=C1
Biological Activity: Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil is a potent antiarrhythmic and vasodilator agent[3].
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Gallopamil | Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. | |||||||||||||||||||||
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- [1]. Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. [Content Brief]
- [2]. Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. [Content Brief]
- [3]. Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21. [Content Brief]
Keywords
