O-7460
Based on 1 Customer Validation
O-7460 is a potent and selective DAGLα inhibitor, with an IC50 of 0.69 μM. O-7460 shows selectivity over onoacylglycerol lipase (MAGL), human CB1 and CB2 cannabinoid receptors. O-7460 can decrease HFD-caused an up-regulation of 2-AG levels.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.0%
- CAS 番号: 1572051-31-0
- 分子式: C25H48FO5P
- 分子量:478.62
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保管条件:
Solution, -20°C, 2 years
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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DAGLα |
O-7460 (10 μM; 20 min) decreases the Ionomycin (3 μM)-induced formation of 2-AG in N18TG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
O-7460 (12 mg/kg; i.p.) decreases the HFD-caused an up-regulation of 2-AG levels in the hypothalamus and liver of mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Seven-week-old male C57BL/6N inbred mice were administrated high-fat diet (HFD) diet[1]
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Dosage:6, 12 mg/kg
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Administration:A single i.p.
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Result:Induced a time (30 min, 60 min and 14 h after O-7460 administration) and dose-dependent decrease in HFD intake.
The highest dose significantly counteracted the body weight increase.
化学情報
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CAS 番号 1572051-31-0
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性状 Liquid
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分子量 478.62
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分子式 C25H48FO5P
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Color Colorless to light yellow
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SMILES
CC(OCC(COP(F)(C)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Solution, -20°C, 2 years
純度とドキュメンテーション
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データシート (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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