Antioxidant and antiviral activities of silybin fatty acid conjugates

  • Eur J Med Chem. 2010 Mar;45(3):1059-67. doi: 10.1016/j.ejmech.2009.11.056.
Radek Gazák  1 ,  Katerina Purchartová ,  Petr Marhol ,  Lucie Zivná ,  Petr Sedmera ,  Katerina Valentová ,  Nobuo Kato ,  Hiroyo Matsumura ,  Kunihiro Kaihatsu ,  Vladimír Kren
Affiliations
  • 1. Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídenská 1083, CZ-142 20 Prague, Czech Republic.
PMID: 20036447 DOI: 10.1016/j.ejmech.2009.11.056
Abstract

Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety.