Delayed DNase-I Administration but Not Gasdermin-D Inhibition Induces Hemorrhagic Transformation After Transient Focal Cerebral Ischemia in Mice

  • Stroke. 2024 Nov;55(11):e297-e299. doi: 10.1161/STROKEAHA.124.047862.
Dongpei Yin  1  2 ,  Chen Wang  1  2 ,  Vikramjeet Singh  3 ,  Ali Ata Tuz  3 ,  Thorsten R Doeppner  4 ,  Matthias Gunzer  3  5 ,  Dirk M Hermann  1  2
Affiliations
  • 1. Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Germany (D.Y., C.W., D.M.H.).
  • 2. Center for Translational and Behavioral Neurosciences, University Hospital Essen, University of Duisburg-Essen, Germany (D.Y., C.W., D.M.H.).
  • 3. Institute of Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Germany (V.S., A.A.T., M.G.).
  • 4. Department of Neurology, University Hospital Gießen, Justus-Liebig-University Gießen, Germany (T.R.D.).
  • 5. Leibniz-Institut für Analytische Wissenschaften e.V. (ISAS), Dortmund, Germany (M.G.).
PMID: 39344516 DOI: 10.1161/STROKEAHA.124.047862
Keywords
hemorrhagic transformation; ischemic stroke; middle cerebral artery occlusion; neutrophil extracellular trap; polymorphonuclear neutrophil.
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