EIF1 - eukaryotic translation initiation factor 1 Gene

Also Known as A121; ISO1; SUI1; EIF-1; EIF1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10209

About EIF1

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,688,885-41,692,668 (from NCBI)

This gene has 7 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 681.9), fat (RPKM 274.0) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in regulation of translational initiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

EIF1 Products (1)

mRNA Protein Name
NM_005801.4 NP_005792.1 eukaryotic translation initiation factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22813744 GOA
enables ribosomal small subunit binding IDA
IDA: Inferred from direct assay
14600024 GOA
enables translation initiation factor activity IDA
IDA: Inferred from direct assay
12435632 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of translational initiation IDA
IDA: Inferred from direct assay
22156057 GOA
involved in translational initiation IDA
IDA: Inferred from direct assay
9732867 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12426392 GOA
part of eukaryotic 43S preinitiation complex IDA
IDA: Inferred from direct assay
9732867 GOA
part of eukaryotic 48S preinitiation complex IDA
IDA: Inferred from direct assay
9732867 GOA
part of multi-eIF complex IDA
IDA: Inferred from direct assay
9732867 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12426392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF1 Protein Structure

SUI1

SUI1: Translation initiation factor SUI1 (26 - 103)

  • 0
  • 100
  • 113 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 1

  • protein translation factor SUI1 homolog

EIF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF1 P41567 EIF3C Homo sapiens Q99613
Pull Down
23623729
Intra
EIF1 P41567 EIF3A Homo sapiens Q14152
Pull Down
23623729
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF1 Proteins

Cat. No. Product Name Accession Purity
HY-P700519 EIF1 Protein, Human (GST) P41567 (M1-F113) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Leukoencephalopathy With Vanishing White Matter

  • Cree Leukoencephalopathy

  • Vanishing White Matter Disease

  • Ovarioleukodystrophy

  • Vanishing White Matter Leukodystrophy

  • Childhood Ataxia With Central Nervous System Hypomyelinization

  • Cach

  • Cach Syndrome

  • Myelinosis Centralis Diffusa

  • VWM

  • Cle

  • Childhood Ataxia With Central Nervous System Hypomyelination

  • Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

  • Cach/Vwm

  • Cach/Vwm Syndrome

  • Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

  • Cree Leukoencehalopathy

  • Late Infantile Cach Syndrome

  • Juvenile Or Adult Cach Syndrome

  • Congenital Or Early Infantile Cach Syndrome

  • Leukodystrophy With Vanishing White Matter
Mehmo Syndrome

  • Mental Retardation, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity

  • MEHMO

  • Mrxs20

  • Mrxs25

  • X-Linked Intellectual Disability-Epileptic Seizures-Hypogenitalism-Microcephaly-Obesity Syndrome

  • Mrxsbrk

  • Mental Retardation, X-Linked, Syndromic 20

  • Mental Retardation, X-Linked, Syndromic 25

  • Mental Retardation, X-Linked, Syndromic, Borck Type

  • Syndromic X-Linked Mental Retardation 20

  • Syndromic X-Linked Mental Retardation 25

  • Intellectual Disability, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity

  • X-Linked Mehmo Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04237 EIF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04238 EIF1AX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04239 EIF1AY Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04240 EIF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18660 Eif1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19594 Eif1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20152 Eif1ax Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25146 Eif1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26090 Eif1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26656 Eif1ax Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris EIF1 VGNC VGNC:40253
Bos taurus EIF1 VGNC VGNC:57141
Rattus norvegicus EIF1 RGD RGD:1306308
Mus musculus EIF1 MGD MGI:105125
Others EIF1 NCBI