SPRED2 - sprouty related EVH1 domain containing 2 Gene

Also Known as NS14; Spred-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 200734

About SPRED2

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:65,307,175-65,432,599 (from NCBI)

This gene has 8 transcripts (splice variants), 278 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 9.3), fat (RPKM 9.2) and 25 other tissues.

Summary

SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

SPRED2 Products (2)

mRNA Protein Name
NM_001128210.2 NP_001121682.1 sprouty-related, EVH1 domain-containing protein 2 isoform b
NM_181784.3 NP_861449.2 sprouty-related, EVH1 domain-containing protein 2 isoform a
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19822672 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20736167 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
20736167 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPRED2 Protein Structure

WH1

WH1: WH1 domain (14 - 118)

Sprouty

Sprouty: Sprouty protein (Spry) (306 - 411)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 418 a.a.
Protein Preferred Names Protein Names

sprouty-related, EVH1 domain-containing protein 2

  • sprouty protein with EVH-1 domain 2, related sequence

SPRED2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPRED2 Q7Z698 KRTAP12-2 Homo sapiens P59991 32296183
Intra
SPRED2 Q7Z698 KRTAP12-2 Homo sapiens P59991 32296183
Intra
SPRED2 Q7Z698 RPS6KA3 Homo sapiens P51812 32814053
Intra
SPRED2 Q7Z698 RPS6KA3 Homo sapiens P51812 32814053
Intra
SPRED2 Q7Z698 RPS6KA3 Homo sapiens P51812 32814053
Intra
SPRED2 Q7Z698 RPS6KA3 Homo sapiens P51812 28514442
Intra
SPRED2 Q7Z698 NEK7 Homo sapiens Q8TDX7 32814053
Intra
SPRED2 Q7Z698 NEK7 Homo sapiens Q8TDX7 32814053
Intra
SPRED2 Q7Z698 NEK7 Homo sapiens Q8TDX7 32814053
Intra
SPRED2 Q7Z698 DNM2 Homo sapiens P50570-2 32814053
Intra
SPRED2 Q7Z698 DNM2 Homo sapiens P50570-2 32814053
Intra
SPRED2 Q7Z698 DNM2 Homo sapiens P50570-2 32814053
Intra
SPRED2 Q7Z698 KIF1B Homo sapiens O60333-2 32814053
Intra
SPRED2 Q7Z698 KIF1B Homo sapiens O60333-2 32814053
Intra
SPRED2 Q7Z698 KIF1B Homo sapiens O60333-2 32814053
Intra
SPRED2 Q7Z698 DMWD Homo sapiens G5E9A7 32814053
Intra
SPRED2 Q7Z698 DMWD Homo sapiens G5E9A7 32814053
Intra
SPRED2 Q7Z698 DMWD Homo sapiens G5E9A7 32814053
Intra
SPRED2 Q7Z698 KPRP Homo sapiens Q5T749 32296183
Intra
SPRED2 Q7Z698 KPRP Homo sapiens Q5T749 32296183
Intra
SPRED2 Q7Z698 LCE2B Homo sapiens O14633 32296183
Intra
SPRED2 Q7Z698 LCE2B Homo sapiens O14633 32296183
Intra
SPRED2 Q7Z698 LCE5A Homo sapiens Q5TCM9 32296183
Intra
SPRED2 Q7Z698 LCE5A Homo sapiens Q5TCM9 32296183
Intra
SPRED2 Q7Z698 ZNF837 Homo sapiens Q96EG3 32296183
Intra
SPRED2 Q7Z698 ZNF837 Homo sapiens Q96EG3 32296183
Intra
SPRED2 Q7Z698 ZNF837 Homo sapiens Q96EG3 32296183
Intra
SPRED2 Q7Z698 LCE1C Homo sapiens Q5T751 32296183
Intra
SPRED2 Q7Z698 LCE1C Homo sapiens Q5T751 32296183
Intra
SPRED2 Q7Z698 NDUFB7 Homo sapiens P17568 32296183
Intra
SPRED2 Q7Z698 NDUFB7 Homo sapiens P17568 32296183
Intra
SPRED2 Q7Z698 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
SPRED2 Q7Z698 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
SPRED2 Q7Z698 KRTAP2-4 Homo sapiens Q9BYR9 32296183
Intra
SPRED2 Q7Z698 ZNF575 Homo sapiens Q86XF7 32296183
Intra
SPRED2 Q7Z698 GLE1 Homo sapiens Q53GS7 32814053
Intra
SPRED2 Q7Z698 GLE1 Homo sapiens Q53GS7 32814053
Intra
SPRED2 Q7Z698 GLE1 Homo sapiens Q53GS7 32814053
Intra
SPRED2 Q7Z698 TSNAX Homo sapiens Q99598 32296183
Intra
SPRED2 Q7Z698 TSNAX Homo sapiens Q99598 32296183
Intra
SPRED2 Q7Z698 TSNAX Homo sapiens Q99598 32296183
Intra
SPRED2 Q7Z698 APBB2 Homo sapiens Q92870-2 32814053
Intra
SPRED2 Q7Z698 APBB2 Homo sapiens Q92870-2 32814053
Intra
SPRED2 Q7Z698 APBB2 Homo sapiens Q92870-2 32814053
Intra
SPRED2 Q7Z698 KCNIP1 Homo sapiens Q9NZI2-2 32296183
Intra
SPRED2 Q7Z698 KCNIP1 Homo sapiens Q9NZI2-2 32296183
Intra
SPRED2 Q7Z698 KCNIP1 Homo sapiens Q9NZI2-2 32296183
Intra
SPRED2 Q7Z698 CHAT Homo sapiens P28329-3 32814053
Intra
SPRED2 Q7Z698 CHAT Homo sapiens P28329-3 32814053
Intra
SPRED2 Q7Z698 CHAT Homo sapiens P28329-3 32814053
Intra
SPRED2 Q7Z698 FGFR3 Homo sapiens P22607 32814053
Intra
SPRED2 Q7Z698 FGFR3 Homo sapiens P22607 32814053
Intra
SPRED2 Q7Z698 FGFR3 Homo sapiens P22607 32814053
Intra
SPRED2 Q7Z698 TOP3B Homo sapiens O95985 25416956
Intra
SPRED2 Q7Z698 TOP3B Homo sapiens O95985 29892012
Intra
SPRED2 Q7Z698 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
SPRED2 Q7Z698 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
SPRED2 Q7Z698 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
SPRED2 Q7Z698 RBM48 Homo sapiens Q5RL73 32296183
Intra
SPRED2 Q7Z698 RBM48 Homo sapiens Q5RL73 32296183
Intra
SPRED2 Q7Z698 PMP22 Homo sapiens A0A6Q8PF08 32814053
Intra
SPRED2 Q7Z698 PMP22 Homo sapiens A0A6Q8PF08 32814053
Intra
SPRED2 Q7Z698 PMP22 Homo sapiens A0A6Q8PF08 32814053
Intra
SPRED2 Q7Z698 SPRED1 Homo sapiens Q7Z699 32814053
Intra
SPRED2 Q7Z698 SPRED1 Homo sapiens Q7Z699 32814053
Intra
SPRED2 Q7Z698 SPRED1 Homo sapiens Q7Z699 32814053
Intra
SPRED2 Q7Z698 ZDHHC17 Homo sapiens Q8IUH5 33961781
Intra
SPRED2 Q7Z698 ZDHHC17 Homo sapiens Q8IUH5 24705354
Intra
SPRED2 Q7Z698 ZDHHC17 Homo sapiens Q8IUH5 24705354
Intra
SPRED2 Q7Z698 NDUFV2 Homo sapiens P19404 32814053
Intra
SPRED2 Q7Z698 NDUFV2 Homo sapiens P19404 32814053
Intra
SPRED2 Q7Z698 NDUFV2 Homo sapiens P19404 32814053
Intra
SPRED2 Q7Z698 WFS1 Homo sapiens O76024 32814053
Intra
SPRED2 Q7Z698 WFS1 Homo sapiens O76024 32814053
Intra
SPRED2 Q7Z698 WFS1 Homo sapiens O76024 32814053
Intra
SPRED2 Q7Z698 RPS6KA6 Homo sapiens Q9UK32 32296183
Intra
SPRED2 Q7Z698 MDFI Homo sapiens Q99750 32296183
Intra
SPRED2 Q7Z698 MDFI Homo sapiens Q99750 32296183
Intra
SPRED2 Q7Z698 MDFI Homo sapiens Q99750 32296183
Intra
SPRED2 Q7Z698 ZNF417 Homo sapiens Q8TAU3 32296183
Intra
SPRED2 Q7Z698 VSNL1 Homo sapiens P62760 32296183
Intra
SPRED2 Q7Z698 VSNL1 Homo sapiens P62760 32296183
Intra
SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8 32296183
Intra
SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8 31515488
Intra
SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8 25416956
Intra
SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8 32296183
Intra
SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8 25416956
Intra
SPRED2 Q7Z698 SPG21 Homo sapiens Q9NZD8 32296183
Intra
SPRED2 Q7Z698 ZNF414 Homo sapiens Q96IQ9 32296183
Intra
SPRED2 Q7Z698 GFAP Homo sapiens P14136 32814053
Intra
SPRED2 Q7Z698 GFAP Homo sapiens P14136 32814053
Intra
SPRED2 Q7Z698 GFAP Homo sapiens P14136 32814053
Intra
SPRED2 Q7Z698 PRPS1 Homo sapiens P60891 32814053
Intra
SPRED2 Q7Z698 PRPS1 Homo sapiens P60891 32814053
Intra
SPRED2 Q7Z698 PRPS1 Homo sapiens P60891 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 14
  • NS14

Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Pseudo-Turner Syndrome
  • Noonan Syndrome

Legius Syndrome
  • Neurofibromatosis Type 1-Like Syndrome

  • Nfls

  • LGSS

  • Neurofibromatosis 1-Like Syndrome

  • Neurofibromatosis Type 1 Like Syndrome

  • Nf1-Like Syndrome

  • Neurofibromatosis, Type 1-Like Syndrome

Rasopathy
  • Ras/Mitogen-Activated Protein Kinase Syndrome

Retinitis Pigmentosa
  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta SPRED2 VGNC VGNC:106225
Canis familiaris SPRED2 VGNC VGNC:46763
Bos taurus SPRED2 VGNC VGNC:58416
Mus musculus SPRED2 MGD MGI:2150019
Rattus norvegicus SPRED2 RGD RGD:1309304
Felis catus SPRED2 VGNC VGNC:65647
Others SPRED2 NCBI