PROX2 - prospero homeobox 2 Gene

Also Known as PROX-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 283571

About PROX2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:74,853,033-74,876,145 (from NCBI)

This gene has 3 transcripts (splice variants), 263 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PROX2 Products (3)

mRNA Protein Name
NM_001080408.3 NP_001073877.2 prospero homeobox protein 2 isoform 2
NM_001243007.2 NP_001229936.1 prospero homeobox protein 2 isoform 1
NM_001384314.1 NP_001371243.1 prospero homeobox protein 2 isoform 1

PROX2 Protein Structure

HPD

HPD: Homeo-prospero domain (439 - 590)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
Protein Preferred Names Protein Names

prospero homeobox protein 2

  • homeobox prospero-like protein PROX2

Related Diseases

Diseases Alias
Atrial Septal Defect 6

  • ASD6

  • Atrial Heart Septal Defect 6

  • Septal Defect, Atrial, Type 6
Atrial Septal Defect 5

  • ASD5

  • Atrial Heart Septal Defect 5

  • Septal Defect, Atrial, Type 5
Congenital Central Hypoventilation Syndrome

  • Cchs

  • Haddad Syndrome

  • Ondine Curse

  • Ondine Syndrome

  • Congenital Central Hypoventilation

  • Congenital Central Alveolar Hypoventilation Syndrome

  • Congenital Failure Of Autonomic Control

  • Ondine'S Curse

  • Primary Alveolar Hypoventilation

  • Ondine-Hirschsprung Disease

  • Central Congenital Hypoventilation Syndrome

  • Congenital Ondine Curse

  • Idiopathic Congenital Central Alveolar Hypoventilation

  • Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

  • Ondine-Hirschsprung Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11204 PROX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PROX2 VGNC VGNC:99228
Canis familiaris PROX2 VGNC VGNC:45018
Mus musculus PROX2 MGD MGI:1920672
Bos taurus PROX2 VGNC VGNC:33370
Felis catus PROX2 VGNC VGNC:64368
Rattus norvegicus PROX2 RGD RGD:1310315
Others PROX2 NCBI