Mapkapk2 - MAPK activated protein kinase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 289014

About Mapkapk2

Primary_assembly 13: 42,513,762-42,560,457 reverse strand.mRatBN7.2:CM026986.1

This gene has 3 transcripts (splice variants), 238 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in Heart (RPKM 849.3), Muscle (RPKM 59.4) and 9 other tissues.

Summary

Predicted to enable Calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of gene expression; and response to lipopolysaccharide. Predicted to act upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mapkapk2 Products (1)

mRNA Protein Name
NM_178102.2 NP_835203.1 MAP kinase-activated protein kinase 2

Mapkapk2 Protein Structure

STKc_MAPKAPK2

STKc_MAPKAPK2: cd14170 (46 - 348)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

MAP kinase-activated protein kinase 2

  • mitogen-activated protein kinase-activated protein kinase 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16129 CBP-501 Inhibitor 99.75% Phase 2
HY-16129A CBP-501 acetate Inhibitor 99.75% Phase 2

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107427 PF-3644022 Inhibitor 99.91% Unkown
HY-131249 MK2-IN-3 Inhibitor 99.15% Unkown
HY-12834A MK2-IN-1 hydrochloride Inhibitor 98.36% Unkown
HY-112457 MK2-IN-3 hydrate Inhibitor 99.08% Unkown
HY-148061 DB1113 99.86% Unkown
HY-12834 MK2-IN-1 Inhibitor 99.04% Unkown
HY-148063 DB0614 96.07% Unkown
HY-147283 MK2-IN-4 Inhibitor / Unkown
HY-175809 SRT6 Inhibitor / Unkown
HY-182596 INHIB1X Inhibitor / Unkown
HY-P10367 Ziptide / Unkown
HY-RS08131 MAPKAPK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08132 Mapkapk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08133 Mapkapk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapkapk2 NCBI NCBI:9261