SRT6
SRT6 is a CD44 inhibitor. SRT6 exerts antiproliferative activity in CD44+ breast cancer and lung cancer cells. SRT6 inhibits CD44-associated SRC kinase, as well as EGFR, ERBB2, ERBB4, MAP3K10 and MAPKAPK2. SRT6 can be used for the research of breast cancer and lung cancer.
For research use only. We do not sell to patients.
- Formula: C25H26N2O8S
- Molecular Weight:514.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All EGFR Isoforms
More
Biological Activity
SRT6 (0.01-100 μM; 5 days) inhibits the proliferation of CD44+ MDA-MB-231, A549, and NCI-H23 cells, with EC50 values of 7.57, 5, and 1.37 μM, respectively[1].
The antiproliferative activity of SRT6 (7.57 μM; 5 days) against MDA-MB-231 breast cancer cells decreases by 13% after blocking CD44 with an anti-CD44 antibody, confirming that this activity is mediated by CD44[1].
SRT6 (5 μM-50 μM) potently inhibits CD44-associated SRC kinase, and also inhibits EGFR, ERBB2, ERBB4, MAP3K10 and MAPKAPK2 at a concentration of 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:CD44+ MDA-MB-231 human breast adenocarcinoma cells
-
Concentration:0.01-100 μM
-
Incubation Time:5 days
-
Result:Inhibited MDA-MB-231 cell proliferation with an EC50 of 7.57 μM, as calculated from 10-point semilog dose-response curves.
Inhibited A549 cell proliferation with an EC50 of 5.00 μM, as calculated from 10-point semilog dose-response curves.
Inhibited NCI-H23 cell proliferation with an EC50 of 1.37 μM, as calculated from 10-point semilog dose-response curves.
-
Cell Line:CD44+ MDA-MB-231 human breast adenocarcinoma cells
-
Concentration:7.57 μM
-
Incubation Time:5 days (SRT6 incubation); 30 min (anti-CD44 antibody pre-incubation)
-
Result:Had its antiproliferative activity reduced by 13% compared to cells treated with SRT6 alone, confirming CD44 as a primary target.
Chemical Information
-
Molecular Weight 514.55
-
Formula C25H26N2O8S
-
SMILES
O=S(C1=CC=C([N+]([O-])=O)C=C1)(OC2=CC=CC3=C2CCN(CC4=CC(OC)=C(OC)C(OC)=C4)C3)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SRT6 Related Classifications
HY-175809 Related Classifications
Powered by Bioz