2. Immunology/Inflammation Protein Tyrosine Kinase/RTK JAK/STAT Signaling MAPK/ERK Pathway
  3. CD44 Src EGFR MAPKAPK2 (MK2)
  4. SRT6

SRT6 is a CD44 inhibitor. SRT6 exerts antiproliferative activity in CD44+ breast cancer and lung cancer cells. SRT6 inhibits CD44-associated SRC kinase, as well as EGFR, ERBB2, ERBB4, MAP3K10 and MAPKAPK2. SRT6 can be used for the research of breast cancer and lung cancer.

For research use only. We do not sell to patients.

SRT6

SRT6 Chemical Structure

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SRT6 Related Antibodies

Top Publications Citing Use of Products

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SRT6 is a CD44 inhibitor. SRT6 exerts antiproliferative activity in CD44+ breast cancer and lung cancer cells. SRT6 inhibits CD44-associated SRC kinase, as well as EGFR, ERBB2, ERBB4, MAP3K10 and MAPKAPK2. SRT6 can be used for the research of breast cancer and lung cancer[1].

In Vitro

SRT6 (0.01-100 μM; 5 days) inhibits the proliferation of CD44+ MDA-MB-231, A549, and NCI-H23 cells, with EC50 values of 7.57, 5, and 1.37 μM, respectively[1].
The antiproliferative activity of SRT6 (7.57 μM; 5 days) against MDA-MB-231 breast cancer cells decreases by 13% after blocking CD44 with an anti-CD44 antibody, confirming that this activity is mediated by CD44[1].
SRT6 (5 μM-50 μM) potently inhibits CD44-associated SRC kinase, and also inhibits EGFR, ERBB2, ERBB4, MAP3K10 and MAPKAPK2 at a concentration of 50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SRT6 Related Antibodies

Cell Viability Assay[1]

Cell Line: CD44+ MDA-MB-231 human breast adenocarcinoma cells
Concentration: 0.01-100 μM
Incubation Time: 5 days
Result: Inhibited MDA-MB-231 cell proliferation with an EC50 of 7.57 μM, as calculated from 10-point semilog dose-response curves.
Inhibited A549 cell proliferation with an EC50 of 5.00 μM, as calculated from 10-point semilog dose-response curves.
Inhibited NCI-H23 cell proliferation with an EC50 of 1.37 μM, as calculated from 10-point semilog dose-response curves.

Cell Viability Assay[1]

Cell Line: CD44+ MDA-MB-231 human breast adenocarcinoma cells
Concentration: 7.57 μM
Incubation Time: 5 days (SRT6 incubation); 30 min (anti-CD44 antibody pre-incubation)
Result: Had its antiproliferative activity reduced by 13% compared to cells treated with SRT6 alone, confirming CD44 as a primary target.
Molecular Weight

514.55

Formula

C25H26N2O8S
SMILES

O=S(C1=CC=C([N+]([O-])=O)C=C1)(OC2=CC=CC3=C2CCN(CC4=CC(OC)=C(OC)C(OC)=C4)C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SRT6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRT6SRT 6SRT-6CD44SrcEGFRMAPKAPK2 (MK2)In (Lu)-related protein p80Pgp-1/Ly-24ECMRIIIHUTCH-1Epidermal growth factor receptorErbB-1HER1Mitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2A549 cellsNCI-H23 cellsCCD-16Lu lung fibroblastsCD44-HABD domainERBB2hyaluronic acidSRC kinaseMDA-MB-231 cellsbreast cancerlung cancerInhibitorinhibitorinhibit

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